咪洛克生
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| 识别信息 | |
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| CAS号 | 81167-16-0  |
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| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C14H16N2O2 |
| 摩尔质量 | 244.29 g·mol−1 |
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咪洛克生（INN：imiloxan）是一种用于科学研究的药物。它作为α2B肾上腺素受体的选择性拮抗剂，[1]可用于区分不同α2肾上腺素亚型的作用。[2][3]
合成
[编辑]
咪洛克生的咪唑部分是通过亚胺酸酯与氨基乙醛的二乙缩醛反应制备的。咪唑与碘乙烷的N-烷基化可得到咪洛克生。
参考资料
[编辑]- ^ Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. British Journal of Pharmacology. March 1990, 99 (3): 560–4. PMC 1917331
. PMID 1970500. doi:10.1111/j.1476-5381.1990.tb12968.x.
- ^ Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D. Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats. European Journal of Pharmacology. January 2007, 554 (2–3): 205–11. PMID 17109851. doi:10.1016/j.ejphar.2006.09.068.
- ^ Romero TR, de Castro Perez A, de Francischi JN, Gama Duarte ID. Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine. European Journal of Pharmacology. April 2009, 608 (1–3): 23–7. PMID 19236861. doi:10.1016/j.ejphar.2009.02.019 .
- ^ Caroon JM, Clark RD, Kluge AF, Olah R, Repke DB, Unger SH, et al. Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists. Journal of Medicinal Chemistry. June 1982, 25 (6): 666–70. PMID 6124635. doi:10.1021/jm00348a012.
