磷酸甘油酸脱氢酶

磷酸甘油酸脱氢酶
命名 系统命名 3-phospho-D-glycerate:NAD+ 2-oxidoreductase 缩写 PHGDH 别名 D-3-phosphoglycerate:NAD+ oxidoreductase; α-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD+ 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase; αKG reductase; D- and L-HGA
识别码
EC編號	1.1.1.95
CAS号	9075-29-0
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
搜索 PMC 相关文献 PubMed 相关文献

磷酸甘油酸脱氢酶
磷酸甘油酸的晶体结构（PDB 2g76）
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 2G76
标识
代号	PHGDH; 3-PGDH; 3PGDH; PDG; PGAD; PGD; PGDH; SERA
扩展标识	遗传学：606879 鼠基因：1355330 同源基因：39318 GeneCards: PHGDH Gene
EC編號	1.1.1.95
基因本体论描述 分子功能 · phosphoglycerate dehydrogenase activity · phosphoglycerate dehydrogenase activity · electron carrier activity · NAD binding 细胞成分 · cytosol 生物过程 · glutamine metabolic process · glycine metabolic process · L-serine biosynthetic process · L-serine biosynthetic process · threonine metabolic process · brain development · cellular amino acid biosynthetic process · gamma-aminobutyric acid metabolic process · regulation of gene expression · taurine metabolic process · spinal cord development · glial cell development · neural tube development · cell cycle process · neuron projection development · cellular nitrogen compound metabolic process · small molecule metabolic process Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	26227	236539
Ensembl	ENSG00000092621	ENSMUSG00000053398
UniProt	O43175	Q61753
mRNA序列	NM_006623.3	NM_016966.3
蛋白序列	NP_006614.2	NP_058662.2
基因位置	Chr 1: 120.2 – 120.29 Mb	Chr 3: 98.12 – 98.14 Mb
PubMed查询	[1]	[2]

磷酸甘油酸脱氢酶（英語：phosphoglycerate dehydrogenase，EC 1.1.1.95 （页面存档备份，存于互联网档案馆）），是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下两种酶促反应：

3-磷酸化-D-甘油酸 + NAD⁺ $\rightleftharpoons$ 3-磷酸羟基丙酮酸 + NADH + H⁺

2-羟基戊二酸 + NAD⁺ $\rightleftharpoons$ α-酮戊二酸 + NADH + H⁺

在大肠杆菌（Escherichia coli）中，磷酸甘油酸脱氢酶参与催化丝氨酸生物合成的磷酸丝氨酸途径中的第一步，上述可逆反应主要逆向进行。磷酸甘油酸脱氢酶可被丝氨酸或甘氨酸抑制。这种酶很不寻常，因为它还能像D-2-羟基戊二酸脱氢酶和L-2-羟基戊二酸脱氢酶一样还原α-酮戊二酸，其中，D型底物更适合磷酸甘油酸脱氢酶。

参考文献

• Sugimoto, E. and Pizer, L.I. The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 1968, 243: 2081–1089. PMID 4384871. 
• Schuller, D.J., Grant, G.A. and Banaszak, L.J. The allosteric ligand site in the V_max-type cooperative enzyme phosphoglycerate dehydrogenase. Nat. Struct. Biol. 1995, 2: 69–76. PMID 7719856. 

扩展阅读

• Tsang HT, Connell JW, Brown SE; et al. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.. Genomics. 2006, 88 (3): 333–346. PMID 16730941. doi:10.1016/j.ygeno.2006.04.003.  引文格式1维护：显式使用等标签 (link)
• Gregory SG, Barlow KF, McLay KE; et al. The DNA sequence and biological annotation of human chromosome 1.. Nature. 2006, 441 (7091): 315–321. PMID 16710414. doi:10.1038/nature04727.  引文格式1维护：显式使用等标签 (link)
• Guo D, Han J, Adam BL; et al. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.. Biochem. Biophys. Res. Commun. 2005, 337 (4): 1308–18. PMID 16236267. doi:10.1016/j.bbrc.2005.09.191.  引文格式1维护：显式使用等标签 (link)
• Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link)
• Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–45. PMID 14702039. doi:10.1038/ng1285.  引文格式1维护：显式使用等标签 (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link)
• Pind S, Slominski E, Mauthe J; et al. V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.. J. Biol. Chem. 2002, 277 (9): 7136–7143. PMID 11751922. doi:10.1074/jbc.M111419200.  引文格式1维护：显式使用等标签 (link)
• Klomp LW, de Koning TJ, Malingré HE; et al. Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.. Am. J. Hum. Genet. 2001, 67 (6): 1389–1399. PMC 1287916 . PMID 11055895. doi:10.1086/316886.  引文格式1维护：显式使用等标签 (link)
• Pineda M, Vilaseca MA, Artuch R; et al. 3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.. Developmental medicine and child neurology. 2000, 42 (9): 629–633. PMID 11034457. doi:10.1017/S0012162200001171.  引文格式1维护：显式使用等标签 (link)
• Baek JY, Jun DY, Taub D, Kim YH. Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization.. Cytogenet. Cell Genet. 2000, 89 (1-2): 6–7. PMID 10894924. doi:10.1159/000015577. 
• Cho HM, Jun DY, Bae MA; et al. Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.. Gene. 2000, 245 (1): 193–201. PMID 10713460. doi:10.1016/S0378-1119(00)00009-3.  引文格式1维护：显式使用等标签 (link)
• Jaeken J, Detheux M, Van Maldergem L; et al. 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.. Arch. Dis. Child. 1996, 74 (6): 542–545. PMC 1511571 . PMID 8758134. doi:10.1136/adc.74.6.542.  引文格式1维护：显式使用等标签 (link)