福山吲哚合成
Fukuyama吲哚合成（福山吲哚合成，Fukuyama indole synthesis），由日本化学家福山透（Fukuyama Tohru）发现。[1]
烯基硫代酰基苯胺在AIBN／三丁基氢化锡体系作用下，环化为2,3-二取代吲哚。[2]
用于含多取代吲哚结构的天然产物合成，如 aspidophytine[3]、长春碱[4]和番木鳖碱[5]。
参见
[编辑]参考资料
[编辑]- ^ Fukuyama, T.; Chen, X.; Peng, G. J. Am. Chem. Soc. 1994, 116, 3127-3128. DOI: 10.1021/ja00086a054
- ^ Tokuyama, H; Yamashita, T; Reding, M. T; Kaburagi, Y; Fukuyama, T. Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles. J. Am. Chem. Soc. 1999, 121: 3791–3792. doi:10.1021/ja983681v.
- ^ Sumi, S; Matsumoto, K; Tokuyama, H; Fukuyama, T. Enantioselective Total Synthesis of Aspidophytine. Org. Lett. 2003, 5 (11): 1891–1893. PMID 12762679. doi:10.1021/ol034445e.
- ^ Yokoshima, S; Ueda, T; Kobayashi, S; Sato, A; Kuboyama, T; Tokuyama, H; Fukuyama, T. Stereocontrolled Total Synthesis of (+)-Vinblastine. J. Am. Chem. Soc. 2002, 124: 2137–2139. doi:10.1021/ja0177049.
- ^ Kaburagi, Y; Tokuyama, H; Fukuyama, T. Total Synthesis of (-)-Strychnine. J. Am. Chem. Soc. 2004, 126 (33): 10246–10247. PMID 15315428. doi:10.1021/ja046407b.