苯丁酸

苯丁酸
英文名	benzenebutanoic acid
别名	γ-苯基丁酸; 4-苯基丁酸; 4-苯基-1-丁酸
识别
CAS号	1821-12-1
SMILES	c1ccccc1CCCC(=O)O;
性质
化学式	C10H12O2
摩尔质量	164.2 g·mol−1
熔点	51 °C（324 K）
沸点	175 °C（448 K）（20 Torr）
相关物质
相关化学品	苯甲酸; 苯乙酸; 苯丙酸
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

苯丁酸是一种有机化合物，化学式为C₁₀H₁₂O₂。

合成

苯丁酸可由3-丙烯酸和硼酸的偶联反应制得。^[2]γ-苯基丁内酯的加氢开环反应也能得到苯丁酸。^[3]

其它合成方法还包括苯丁酸衍生物的水解^[4]^[5]、苯丁醇的氧化^[6]等。

参考文献

^ ^1.0 ^1.1 Reppe, Walter; et al. Ethynylation. VI. Dehydrogenation of γ-diols and reactions of γ-lactones. Annalen der Chemie, Justus Liebigs, 1955. 596. 158-224. CODEN: 9X224Y.
^ Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M. Ligand-controlled regiodivergence in nickel-catalyzed hydroarylation and hydroalkenylation of alkenyl carboxylic acids. ChemRxiv, 2020. pp 1-8. ISSN: 2573-2293.
^ Hoi-Yun Jung, Sukbok Chang, Sungwoo Hong. Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C–H Amidation. Organic Letters. 2019-09-06, 21 (17): 7099–7103 [2020-11-18]. ISSN 1523-7060. doi:10.1021/acs.orglett.9b02673 （英语）.
^ Chandrani Mukherjee, Dunming Zhu, Edward R. Biehl, Ling Hua. Exploring the Synthetic Applicability of a Cyanobacterium Nitrilase as Catalyst for Nitrile Hydrolysis. European Journal of Organic Chemistry. 2006-12, 2006 (23): 5238–5242 [2020-11-18]. doi:10.1002/ejoc.200600699 （英语）.
^ Kiyoshi Tanemura, Taoufik Rohand. Activated charcoal as an effective additive for alkaline and acidic hydrolysis of esters in water. Tetrahedron Letters. 2020-10, 61 (44): 152467 [2020-11-18]. doi:10.1016/j.tetlet.2020.152467 （英语）.
^ Hironori Tsunoyama, Tatsuya Tsukuda, Hidehiro Sakurai. Synthetic Application of PVP-stabilized Au Nanocluster Catalyst to Aerobic Oxidation of Alcohols in Aqueous Solution under Ambient Conditions. Chemistry Letters. 2007-02, 36 (2): 212–213 [2020-11-18]. ISSN 0366-7022. doi:10.1246/cl.2007.212. （原始内容存档于2020-07-01）（英语）.

[Reppe-1] 1.0 ^1.1 Reppe, Walter; et al. Ethynylation. VI. Dehydrogenation of γ-diols and reactions of γ-lactones. Annalen der Chemie, Justus Liebigs, 1955. 596. 158-224. CODEN: 9X224Y.

[2] Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M. Ligand-controlled regiodivergence in nickel-catalyzed hydroarylation and hydroalkenylation of alkenyl carboxylic acids. ChemRxiv, 2020. pp 1-8. ISSN: 2573-2293.

[3] Hoi-Yun Jung, Sukbok Chang, Sungwoo Hong. Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C–H Amidation. Organic Letters. 2019-09-06, 21 (17): 7099–7103 [2020-11-18]. ISSN 1523-7060. doi:10.1021/acs.orglett.9b02673 （英语）.

[4] Chandrani Mukherjee, Dunming Zhu, Edward R. Biehl, Ling Hua. Exploring the Synthetic Applicability of a Cyanobacterium Nitrilase as Catalyst for Nitrile Hydrolysis. European Journal of Organic Chemistry. 2006-12, 2006 (23): 5238–5242 [2020-11-18]. doi:10.1002/ejoc.200600699 （英语）.

[5] Kiyoshi Tanemura, Taoufik Rohand. Activated charcoal as an effective additive for alkaline and acidic hydrolysis of esters in water. Tetrahedron Letters. 2020-10, 61 (44): 152467 [2020-11-18]. doi:10.1016/j.tetlet.2020.152467 （英语）.

[6] Hironori Tsunoyama, Tatsuya Tsukuda, Hidehiro Sakurai. Synthetic Application of PVP-stabilized Au Nanocluster Catalyst to Aerobic Oxidation of Alcohols in Aqueous Solution under Ambient Conditions. Chemistry Letters. 2007-02, 36 (2): 212–213 [2020-11-18]. ISSN 0366-7022. doi:10.1246/cl.2007.212. （原始内容存档于2020-07-01）（英语）.

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