SUZ12

Zeste 12同源物（果蝇属）抑制因子
Zeste 12同源物（果蝇属）抑制因子
标识
代号	SUZ12; CHET9; JJAZ1
扩展标识	遗传学：606245 鼠基因：1261758 同源基因：32256 GeneCards: SUZ12 Gene
基因本体论描述
分子功能	· chromatin binding; · protein binding; · methylated histone residue binding; · histone methyltransferase activity; · sequence-specific DNA binding; · metal ion binding;
细胞成分	· sex chromatin; · ESC/E(Z) complex;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · transcription, DNA-dependent; · positive regulation of cell proliferation; · histone ubiquitination; · negative regulation of cell differentiation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	23512
Ensembl	ENSG00000178691
UniProt	Q15022
mRNA序列	NM_015355
蛋白序列	NP_056170
基因位置	Chr 17:; 30.26 – 30.33 Mb
PubMed查询	[1]
	查; 论; 编;

多梳蛋白SUZ12是由人类SUZ12 基因所编码的蛋白质^[1]^[2]^[3]^[4] 有报导称该锌指基因在子宫内膜基质肉瘤中位于常见染色体易位断裂点上。这些断裂点相互重组导致该基因与JAZF1两者发生融合。该基因编码的蛋白质在编码区域C端包含有一个锌指结构域。目前仍未明确该基因的特异性功能^[4]。

作为多梳抑制复合物2（PRC2）的一部分，SUZ12可能与HOTAIR非编码RNA一起参与到染色质沉默之中，SUZ12利用其锌指结构域与RNA分子进行结合^[5]。

参考文献

^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. Mar 1996, 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167.
^ Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A. May 2001, 98 (11): 6348–53. PMC 33471 . PMID 11371647. doi:10.1073/pnas.101132598.
^ Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB. Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development. Reproduction. Dec 2008, 136 (6): 777–85. PMID 18784248. doi:10.1530/REP-08-0045.
^ ^4.0 ^4.1 Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila). （原始内容存档于2010-03-07）.
^ Rinn JL; Kertesz M; Wang JK; et al. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non-Coding RNAs. Cell. June 2007, 129 (7): 1311–23 [2010-07-20]. PMC 2084369 . PMID 17604720. doi:10.1016/j.cell.2007.05.022. （原始内容存档于2019-02-17）.

深入阅读

Birve A; Sengupta AK; Beuchle D; et al. Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development. 2001, 128 (17): 3371–9. PMID 11546753.
Weinmann AS; Bartley SM; Zhang T; et al. Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters. Mol. Cell. Biol. 2001, 21 (20): 6820–32. PMC 99859 . PMID 11564866. doi:10.1128/MCB.21.20.6820-6832.2001.
Cao R; Wang L; Wang H; et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science. 2002, 298 (5595): 1039–43. PMID 12351676. doi:10.1126/science.1076997.
Kuzmichev A; Nishioka K; Erdjument-Bromage H; et al. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002, 16 (22): 2893–905. PMC 187479 . PMID 12435631. doi:10.1101/gad.1035902.
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Petek E; Jenne DE; Smolle J; et al. Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations. J. Med. Genet. 2003, 40 (7): 520–5. PMC 1735521 . PMID 12843325. doi:10.1136/jmg.40.7.520.
Wang H; An W; Cao R; et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell. 2003, 12 (2): 475–87. PMID 14536086. doi:10.1016/j.molcel.2003.08.007.
Huang HY, Ladanyi M, Soslow RA. Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. Am. J. Surg. Pathol. 2004, 28 (2): 224–32. PMID 15043312. doi:10.1097/00000478-200402000-00010.
Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell. 2004, 15 (1): 57–67. PMID 15225548. doi:10.1016/j.molcel.2004.06.020.
Kehrer-Sawatzki H; Kluwe L; Sandig C; et al. High Frequency of Mosaicism among Patients with Neurofibromatosis Type 1 (NF1) with Microdeletions Caused by Somatic Recombination of the JJAZ1 Gene. Am. J. Hum. Genet. 2004, 75 (3): 410–23. PMC 1182020 . PMID 15257518. doi:10.1086/423624.
Beausoleil SA; Jedrychowski M; Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Pasini D; Bracken AP; Jensen MR; et al. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004, 23 (20): 4061–71. PMC 524339 . PMID 15385962. doi:10.1038/sj.emboj.7600402.
Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Cha TL; Zhou BP; Xia W; et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science. 2005, 310 (5746): 306–10. PMID 16224021. doi:10.1126/science.1118947.
Lee TI; Jenner RG; Boyer LA; et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006, 125 (2): 301–13. PMID 16630818. doi:10.1016/j.cell.2006.02.043.
Furuno K; Masatsugu T; Sonoda M; et al. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Biochem. Biophys. Res. Commun. 2006, 345 (3): 1051–8. PMID 16712789. doi:10.1016/j.bbrc.2006.05.014.
Olsen JV; Blagoev B; Gnad F; et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006, 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Nucci MR; Harburger D; Koontz J; et al. Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am. J. Surg. Pathol. 2007, 31 (1): 65–70. PMID 17197920. doi:10.1097/01.pas.0000213327.86992.d1.

外部链接

FactorBook SUZ12

[pmid8590280-1] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. Mar 1996, 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167.

[pmid11371647-2] Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A. May 2001, 98 (11): 6348–53. PMC 33471 . PMID 11371647. doi:10.1073/pnas.101132598.

[pmid18784248-3] Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB. Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development. Reproduction. Dec 2008, 136 (6): 777–85. PMID 18784248. doi:10.1530/REP-08-0045.

[entrez-4] 4.0 ^4.1 Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila). （原始内容存档于2010-03-07）.

[Rinn-5] Rinn JL; Kertesz M; Wang JK; et al. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non-Coding RNAs. Cell. June 2007, 129 (7): 1311–23 [2010-07-20]. PMC 2084369 . PMID 17604720. doi:10.1016/j.cell.2007.05.022. （原始内容存档于2019-02-17）.

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