2-甲氧基雌三醇

2-甲氧基雌三醇
	IUPAC名; (8R,9S,13S,14S,16R,17R)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
别名	2-MeO-E3
识别
CAS号	1236-72-2
PubChem	102031
ChemSpider	92169
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=CC(=C(C=C34)OC)O;
InChI	1S/C19H26O4/c1-19-6-5-11-12(14(19)9-16(21)18(19)22)4-3-10-7-15(20)17(23-2)8-13(10)11/h7-8,11-12,14,16,18,20-22H,3-6,9H2,1-2H3/t11-,12+,14-,16+,18-,19-/m0/s1;
InChIKey	PEXPJFWTSZLEAQ-YSYMNNNUSA-N
性质
化学式	C19H26O4
摩尔质量	318.41 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2-甲氧基雌三醇（英语：2-Methoxyestriol，缩写2-MeO-E3）是一种内源性的雌激素代谢产物^[1]^[2]^[3]，主要是雌三醇和2-羟基雌三醇的代谢产物^[1]^[2]^[3]。2-MeO-E3对雌激素受体的亲和力极低，基本没有雌激素效应^[4]。但是，2-MeO-E3有一些非雌激素受体介导的降血脂效应^[5]。

参考资料

^ ^1.0 ^1.1 Fishman J, Gallagher TF. 2-Methoxyestriol: a new metabolite of estradiol in man. Arch. Biochem. Biophys. October 1958, 77 (2): 511–3. PMID 13584013. doi:10.1016/0003-9861(58)90097-3.
^ ^2.0 ^2.1 King RJ. Oestriol metabolism by rat- and rabbit-liver slices. Isolation of 2-methoxyoestriol and 2-hydroxyestriol. Biochem. J. May 1961, 79 (2): 355–61. PMC 1205847 . PMID 13756104. doi:10.1042/bj0790355.
^ ^3.0 ^3.1 Fujii Y, Teranishi M, Nakada K, Yamazaki M, Kishida S, Miyabo S. Radioimmunoassay of 2-methoxyestriol in pregnancy plasma. Horm. Metab. Res. September 1988, 20 (9): 599–600. PMID 3198067. doi:10.1055/s-2007-1010895.
^ Martucci CP. The role of 2-methoxyestrone in estrogen action. J. Steroid Biochem. July 1983, 19 (1B): 635–8. PMID 6310247. doi:10.1016/0022-4731(83)90229-7.
^ Kono, Shinzo; Higa, Hiroaki; Sunagawa, Hajime. Hypocholesterolemic Effect of Long-Term Continuous Administration of 2-Methoxyestriol in Dietary Hypercholesterolemic Rats. Journal of Clinical Biochemistry and Nutrition. 1989, 6 (1): 49–56. ISSN 1880-5086. doi:10.3164/jcbn.6.49 .

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