CEBPD

CEBPD
识别号
别名	CEBPD；, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
外部ID	OMIM：116898 MGI：103573 HomoloGene：3808 GeneCards：CEBPD
基因位置（人类）
染色体	8号染色体
终止	47,738,164 bp
基因位置（小鼠）
染色体	小鼠16号染色体
终止	15,708,895 bp
基因本体
分子功能	• DNA结合转录因子活性; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA结合; • sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 血浆蛋白结合; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein homodimerization activity; • protein heterodimerization activity;
细胞组分	• 细胞核; • 核质;
生物学过程	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • cytokine-mediated signaling pathway; • hematopoietic progenitor cell differentiation; • regulation of transcription by RNA polymerase II; • fat cell differentiation; • positive regulation of osteoblast differentiation; • negative regulation of transcription, DNA-templated; • 内耳的发生;
	Sources:Amigo / QuickGO
直系同源
	1052
	12609
	ENSG00000221869
	ENSMUSG00000071637
	P49716
	Q00322
	NM_005195
	NM_007679
	NP_005186
	NP_031705
	维基数据
查看/编辑人类	查看/编辑小鼠

CCAAT/增强子结合蛋白δ，简称C/EBP-δ或CEBPD，是一种在人类中由CEBPD基因编码的蛋白质。^[5]^[6]

功能

由这种无内含子基因编码的蛋白质是一种bZIP转录因子，它可以作为同源二聚体与某些DNA调节区结合。它还可以与相关蛋白C/EBP-α形成异二聚体。编码的蛋白质在调节参与免疫和炎症反应的基因中很重要，并且可能参与调节与巨噬细胞活化和/或分化相关的基因。^[7]

CEBPD参与细胞凋亡和细胞增殖的调节。它可能充当肿瘤抑制因子。^[8]

一项针对小鼠的研究表明，CEBPD在慢性阻塞性肾病进展过程中可防止肾小管损伤和肾小管间质纤维化的发展。^[9]

CEBPD基因的功能可以通过基于独立验证的siRNA敲低来有效检查。^[10]

相互作用

CEBPD已被证明能与SMAD3相互作用。^[11]

参见

CCAAT增强子结合蛋白

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Development. Sep 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .
^ Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes & Development. Sep 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553 .
^ Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta.
^ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP. C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation. Oncogene. Feb 2005, 24 (9): 1589–97. PMID 15674331. doi:10.1038/sj.onc.1208393 .
^ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA. CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy. Laboratory Investigation; A Journal of Technical Methods and Pathology. Jan 2014, 94 (1): 89–97. PMID 24247561. doi:10.1038/labinvest.2013.127 .
^ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments. Molecular Therapy: Nucleic Acids. 2016, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.
^ Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. The Journal of Biological Chemistry. Mar 2003, 278 (11): 9609–19. PMID 12524424. doi:10.1074/jbc.M212259200 .

阅读

Sladek FM, Darnell JE. Mechanisms of liver-specific gene expression. Current Opinion in Genetics & Development. Apr 1992, 2 (2): 256–9. PMID 1638120. doi:10.1016/S0959-437X(05)80282-5.
Kinoshita S, Akira S, Kishimoto T. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proceedings of the National Academy of Sciences of the United States of America. Feb 1992, 89 (4): 1473–6. Bibcode:1992PNAS...89.1473K. PMC 48473 . PMID 1741402. doi:10.1073/pnas.89.4.1473 .
Nagulapalli S, Pongubala JM, Atchison ML. Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). Journal of Immunology. Nov 1995, 155 (9): 4330–8. PMID 7594592.
Wood S, Schertzer M, Yaremko ML. Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p. Cytogenetics and Cell Genetics. 1995, 70 (3–4): 188–91. PMID 7789168. doi:10.1159/000134030.
Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. Genomics. May 1993, 16 (2): 520–3. PMID 8314590. doi:10.1006/geno.1993.1220.
Chen PL, Riley DJ, Chen Y, Lee WH. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes & Development. Nov 1996, 10 (21): 2794–804. PMID 8946919. doi:10.1101/gad.10.21.2794 .
Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. The International Journal of Biochemistry & Cell Biology. Dec 1997, 29 (12): 1525–39. PMID 9570146. doi:10.1016/S1357-2725(97)00083-6.
Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. The Journal of Biological Chemistry. Mar 2002, 277 (9): 6923–8. PMID 11741938. doi:10.1074/jbc.M108075200 .
Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E. C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2. Molecular and Cellular Probes. Dec 2001, 15 (6): 395–7. PMID 11851384. S2CID 8215328. doi:10.1006/mcpr.2001.0377. hdl:11382/3170 .
Gao H, Parkin S, Johnson PF, Schwartz RC. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. The Journal of Biological Chemistry. Oct 2002, 277 (41): 38827–37. PMID 12177065. doi:10.1074/jbc.M206224200 .
Dearth LR, DeWille J. Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells. The Journal of Biological Chemistry. Mar 2003, 278 (13): 11246–55. PMID 12554732. doi:10.1074/jbc.M207930200 .
Milde-Langosch K, Löning T, Bamberger AM. Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. Breast Cancer Research and Treatment. May 2003, 79 (2): 175–85. PMID 12825852. S2CID 45020949. doi:10.1023/A:1023929504884.
Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. The Journal of Biological Chemistry. Sep 2003, 278 (38): 36959–65. PMID 12857754. doi:10.1074/jbc.M303147200 .
Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM. Molecular responses of human muscle to eccentric exercise. Journal of Applied Physiology. Dec 2003, 95 (6): 2485–94. PMID 12937035. S2CID 9817319. doi:10.1152/japplphysiol.01161.2002.
Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiology of Aging. Sep 2004, 25 (8): 991–9. PMID 15212823. S2CID 54232508. doi:10.1016/j.neurobiolaging.2003.10.016.
Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW. CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. Journal of Cellular Biochemistry. Nov 2004, 93 (4): 844–56. PMID 15389878. S2CID 31572695. doi:10.1002/jcb.20224.

外部链接

Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
医学主题词表（MeSH）：CEBPD+protein,+human

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840554-5] Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Development. Sep 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .

[pmid1884998-6] Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes & Development. Sep 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553 .

[entrez-7] Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta.

[pmid_=_15674331-8] Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP. C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation. Oncogene. Feb 2005, 24 (9): 1589–97. PMID 15674331. doi:10.1038/sj.onc.1208393 .

[pmid_=_24247561-9] Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA. CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy. Laboratory Investigation; A Journal of Technical Methods and Pathology. Jan 2014, 94 (1): 89–97. PMID 24247561. doi:10.1038/labinvest.2013.127 .

[10] Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments. Molecular Therapy: Nucleic Acids. 2016, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.

[pmid12524424-11] Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. The Journal of Biological Chemistry. Mar 2003, 278 (11): 9609–19. PMID 12524424. doi:10.1074/jbc.M212259200 .

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