CTLA-4

细胞毒性T淋巴细胞相关抗原4
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3OSK、1AH1、1H6E、1I85、1I8L、2X44、3BX7
识别号
别名	CTLA4；, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
外部ID	OMIM：123890 MGI：88556 HomoloGene：3820 GeneCards：CTLA4
相关疾病
	类风湿性关节炎、甲状腺机能低下症、1型糖尿病、type 1 diabetes mellitus 12、autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
为以下药物的标靶
	伊匹单抗
基因位置（人类）
染色体	2号染色体
终止	203,873,965 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	60,954,991 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 血浆蛋白结合;
细胞组分	• 细胞质的核周区域; • integral component of membrane; • clathrin-coated endocytic vesicle; • 细胞膜; • 高尔基体; • 膜; • external side of plasma membrane; • protein complex involved in cell adhesion; • integral component of plasma membrane;
生物学过程	• B cell receptor signaling pathway; • T cell costimulation; • negative regulation of B cell proliferation; • 适应性免疫; • negative regulation of regulatory T cell differentiation; • 免疫反应; • cellular response to DNA damage stimulus; • immune system process; • positive regulation of apoptotic process; • negative regulation of immune response; • negative regulation of T cell proliferation; • regulation of regulatory T cell differentiation; • regulation of T cell proliferation; • T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	1493
	12477
	ENSG00000163599
	ENSMUSG00000026011
	P16410
	P09793
	NM_001037631; NM_005214
	NM_001281976; NM_009843
	NP_001032720; NP_005205
	NP_001268905; NP_033973
	维基数据
查看/编辑人类	查看/编辑小鼠

CTLA4又称CTLA-4（细胞毒性T淋巴细胞相关抗原4，cytotoxic T-lymphocyte-associated protein 4）或CD152（分化群152），是一种蛋白质受体^[7]。CTLA-4蛋白由小鼠的Ctla4^[8]和人类的CTLA4基因编码^[9]。CTLA-4于1991年首次被发现^[10]。

参考文献

^ 與細胞毒性T淋巴細胞相關抗原4相關的疾病；在維基數據上查看/編輯參考.
^ 對細胞毒性T淋巴細胞相關抗原4起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000163599 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000026011 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.
^ A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.
^ Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.
^ Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.

[1] 與細胞毒性T淋巴細胞相關抗原4相關的疾病；在維基數據上查看/編輯參考.

[2] 對細胞毒性T淋巴細胞相關抗原4起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000163599 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000026011 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-7] De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.

[pmid3496540-8] A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.

[pmid3220103-9] Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.

[Waterhouse_1995-10] Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.

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