TRPC5
短瞬态受体电位通道 5 (Short transient receptor potential channel 5, TrpC5 ) 又称瞬态受体蛋白 5 ( TRP-5 ) ，是一种在人类中由TRPC5基因编码的离子通道蛋白。 [1] [2] [3] TrpC5 是哺乳动物瞬态受体电位离子通道TRPC家族的亚型。
功能
[编辑]TrpC5 是七种哺乳动物TRPC （transient receptor potential canonical）蛋白中的一种。 TrpC5 是一种多次穿膜的膜蛋白，且被认为构成了受体活化型的非选择性钙离子通道。其单独存在时即具有活性，但也能与TRPC1 、 TRPC3和TRPC4组成异质多聚体。此外，其也和多种蛋白质相互作用，包括钙调蛋白(CaM)、 CABP1 、 enkurin 、Na +–H +交换调节因子 ( NHERF )、干扰素诱导的 GTP 结合蛋白 ( MX1 )、RNF24 、SEC14结构域和血影蛋白重复序列蛋白 1 ( SESTD1 )。 [1]
TRPC4 和 TRPC5 与汞毒性[4]和神经行为有关。 [5] TRPC5于2021年被发现是牙齿冷感觉系统的组成部分。 [6] 其还被发现参与如氯仿、氟烷和异丙酚等麻醉剂的作用。 [7]
活化
[编辑]同源多聚体 TRPC5 和异源多聚体 TRPC5- TRPC1通道被细胞外的硫氧还蛋白活化。 [8]
交互作用
[编辑]TRPC5 已被证明与STMN3 、 [9] TRPC1 、 [10] [11]和TRPC4间有交互作用。 [11]
参见
[编辑]参考资料
[编辑]- ^ 1.0 1.1 Entrez Gene: transient receptor potential cation channel. 引用错误：带有name属性“entrez”的
<ref>标签用不同内容定义了多次 - ^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. Genomics. September 1999, 60 (3): 330–40. PMID 10493832. doi:10.1006/geno.1999.5924.
- ^ Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. S2CID 17936350. doi:10.1124/pr.57.4.6.
- ^ Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B. Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicol. Sci. January 2012, 125 (1): 56–68. PMID 21984481. doi:10.1093/toxsci/kfr268
.
- ^ Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. May 15, 2009, 137 (4): 761–72. PMC 2719954 . PMID 19450521. doi:10.1016/j.cell.2009.03.039.
- ^ Bernal, Laura; Sotelo-Hitschfeld, Pamela; König, Christine; Sinica, Viktor; Wyatt, Amanda; Winter, Zoltan; Hein, Alexander; Touska, Filip; Reinhardt, Susanne; Tragl, Aaron; Kusuda, Ricardo. Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances. 2021, 7 (13): eabf5567. PMC 7997515 . PMID 33771873. doi:10.1126/sciadv.abf5567.
- ^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ. Modulation of TRPC5 cation channels by halothane, chloroform and propofol. Br. J. Pharmacol. April 2008, 153 (7): 1505–12. PMC 2437913 . PMID 18204473. doi:10.1038/sj.bjp.0707689.
- ^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ. TRPC channel activation by extracellular thioredoxin. Nature. January 2008, 451 (7174): 69–72. PMC 2645077 . PMID 18172497. doi:10.1038/nature06414.
- ^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. August 2003, 6 (8): 837–45. PMID 12858178. S2CID 7523946. doi:10.1038/nn1092.
- ^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. October 2003, 278 (40): 39014–9. PMID 12857742. doi:10.1074/jbc.M306705200 .
- ^ 11.0 11.1 Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. U.S.A. May 2002, 99 (11): 7461–6. PMC 124253 . PMID 12032305. doi:10.1073/pnas.102596199 .
延伸阅读
[编辑]
- Beech DJ. Canonical transient receptor potential 5. Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology 179. 2007: 109–23. ISBN 978-3-540-34889-4. PMID 17217053. doi:10.1007/978-3-540-34891-7_6.
|journal=被忽略 (帮助);|issue=被忽略 (帮助) - Beech DJ. Bipolar phospholipid sensing by TRPC5 calcium channel. Biochem. Soc. Trans. 2007, 35 (Pt 1): 101–4. PMID 17233612. doi:10.1042/BST0350101.