模板:PBB/1312

儿茶酚-O-甲基转移酶 Catechol-O-methyltransferase
COMT和3,5-dinitrocatechol(深蓝)以及S-腺苷甲硫氨酸(黄)结合。 来自PDB 3BWM.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD, 4XUE
标识
代号	COMT; HEL-S-98n
扩展标识	遗传学：116790 鼠基因：88470 同源基因：30982 ChEMBL: 2023 GeneCards: COMT Gene
EC编号	2.1.1.6
基因本体论描述 分子功能 · magnesium ion binding · protein binding · O-methyltransferase activity · catechol O-methyltransferase activity 细胞成分 · mitochondrion · cytosol · plasma membrane · membrane · integral component of membrane · axon · dendritic spine · cell body · postsynaptic membrane · extracellular exosome 生物过程 · xenobiotic metabolic process · synaptic transmission · female pregnancy · learning · short-term memory · estrogen metabolic process · response to organic cyclic compound · cellular response to phosphate starvation · methylation · response to lipopolysaccharide · developmental process · negative regulation of renal sodium excretion · neurotransmitter catabolic process · neurotransmitter biosynthetic process · dopamine catabolic process · response to drug · small molecule metabolic process · negative regulation of dopamine metabolic process · response to pain · multicellular organismal reproductive process · negative regulation of smooth muscle cell proliferation · positive regulation of homocysteine metabolic process · regulation of sensory perception of pain Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	1312	12846
Ensembl	ENSG00000093010	ENSMUSG00000000326
UniProt	P21964	O88587
mRNA序列	NM_000754	NM_001111062
蛋白序列	NP_000745	NP_001104532
基因位置	Chr 22: 19.94 – 19.97 Mb	Chr 16: 18.41 – 18.43 Mb
PubMed查询	[1]	[2]