模板:PBB/3458

干扰素-γ
干扰素-γ
	γ-干扰素晶体结构线状表示
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1EKU, 1FG9, 1FYH, 1HIG, 3BES
标识
代号	IFNG; IFG; IFI
扩展标识	遗传学：147570 鼠基因：107656 同源基因：55526 GeneCards: IFNG Gene
基因本体论描述
分子功能	· cytokine activity; · interferon-gamma receptor binding;
细胞成分	· extracellular region; · extracellular space; · external side of plasma membrane;
生物过程	· protein import into nucleus, translocation; · negative regulation of transcription from RNA polymerase II promoter; · neutrophil apoptotic process; · regulation of the force of heart contraction; · positive regulation of mesenchymal cell proliferation; · adaptive immune response; · CD8-positive, alpha-beta T cell differentiation involved in immune response; · negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; · apoptotic process; · cellular component movement; · humoral immune response; · cell cycle arrest; · cell surface receptor signaling pathway; · response to virus; · cytokine-mediated signaling pathway; · antigen processing and presentation; · neutrophil chemotaxis; · endoplasmic reticulum unfolded protein response; · negative regulation of myelination; · positive regulation of synaptic transmission, cholinergic; · negative regulation of interleukin-17 production; · positive regulation of interleukin-12 production; · positive regulation of interleukin-23 production; · positive regulation of tumor necrosis factor production; · positive regulation of peptidyl-serine phosphorylation of STAT protein; · positive regulation of smooth muscle cell apoptotic process; · positive regulation of T cell proliferation; · response to drug; · positive regulation of tyrosine phosphorylation of Stat1 protein; · defense response to bacterium; · defense response to protozoan; · negative regulation of growth of symbiont in host; · positive regulation of chemokine biosynthetic process; · positive regulation of interleukin-12 biosynthetic process; · positive regulation of MHC class II biosynthetic process; · positive regulation of interleukin-6 biosynthetic process; · positive regulation of nitric oxide biosynthetic process; · positive regulation of neuron differentiation; · positive regulation of osteoclast differentiation; · positive regulation of cell adhesion; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of isotype switching to IgG isotypes; · negative regulation of smooth muscle cell proliferation; · positive regulation of interleukin-1 beta secretion; · regulation of insulin secretion; · positive regulation of membrane protein ectodomain proteolysis; · defense response to virus; · positive regulation of killing of cells of other organism; · interferon-gamma-mediated signaling pathway; · regulation of interferon-gamma-mediated signaling pathway; · positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; · positive regulation of fructose 1,6-bisphosphate metabolic process; · positive regulation of vitamin D biosynthetic process; · positive regulation of calcidiol 1-monooxygenase activity; · cellular response to lipopolysaccharide; · cellular response to interleukin-18; · negative regulation of metanephric nephron tubule epithelial cell differentiation; · positive regulation of tumor necrosis factor (ligand) superfamily member 11 production;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	3458
Ensembl	ENSG00000111537
UniProt	P01579
mRNA序列	NM_000619
蛋白序列	NP_000610
基因位置	Chr 12:; 68.55 – 68.55 Mb
PubMed查询	[1]
	查; 论; 编;

参考资料

^ PDB 1FG9; Thiel DJ, le Du MH, Walter RL, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. September 2000, 8 (9): 927–36. PMID 10986460. doi:10.1016/S0969-2126(00)00184-2.

[PDB_1FG9-1] PDB 1FG9; Thiel DJ, le Du MH, Walter RL, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. September 2000, 8 (9): 927–36. PMID 10986460. doi:10.1016/S0969-2126(00)00184-2.

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