DU145細胞

DU145（DU-145）是人類前列腺癌細胞系。DU145、PC3和LNCaP被認為是用於治療研究的標準前列腺癌細胞系^[1]。DU145細胞系源自原發性前列腺腺癌的中樞神經系統遠端轉移，在頂枕開顱手術 (parietooccipital craniotomy) 中被切除^[2]。雄激素受體陽性的DU145對激素不敏感，並且不表達前列腺特異抗原。 DU145細胞與具有高轉移潛力的PC3細胞相比，具有中等的轉移潛力^[3]。

參考資料

^ Alimirah, F; Chen, J; Basrawala, Z; Xin, H; Choubey, D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.. FEBS letters. 2006-04-17, 580 (9): 2294–300 [2019-11-25]. PMID 16580667. doi:10.1016/j.febslet.2006.03.041.
^ Stone, KR; Mickey, DD; Wunderli, H; Mickey, GH; Paulson, DF. Isolation of a human prostate carcinoma cell line (DU 145).. International journal of cancer. 1978-03-15, 21 (3): 274–81 [2019-11-25]. PMID 631930. doi:10.1002/ijc.2910210305.
^ Pulukuri, SM; Gondi, CS; Lakka, SS; Jutla, A; Estes, N; Gujrati, M; Rao, JS. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo.. The Journal of biological chemistry. 2005-10-28, 280 (43): 36529–40 [2019-11-25]. PMID 16127174. doi:10.1074/jbc.M503111200.

外部連結

Cellosaurus entry for DU145（頁面存檔備份，存於網際網路檔案館）

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[1] Alimirah, F; Chen, J; Basrawala, Z; Xin, H; Choubey, D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.. FEBS letters. 2006-04-17, 580 (9): 2294–300 [2019-11-25]. PMID 16580667. doi:10.1016/j.febslet.2006.03.041.

[2] Stone, KR; Mickey, DD; Wunderli, H; Mickey, GH; Paulson, DF. Isolation of a human prostate carcinoma cell line (DU 145).. International journal of cancer. 1978-03-15, 21 (3): 274–81 [2019-11-25]. PMID 631930. doi:10.1002/ijc.2910210305.

[3] Pulukuri, SM; Gondi, CS; Lakka, SS; Jutla, A; Estes, N; Gujrati, M; Rao, JS. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo.. The Journal of biological chemistry. 2005-10-28, 280 (43): 36529–40 [2019-11-25]. PMID 16127174. doi:10.1074/jbc.M503111200.

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