模板:PBB/351

Amyloid beta (A4) precursor protein
PDB rendering based on 1aap
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1AAP, 1AMB, 1AMC, 1AML, 1BA4, 1BA6, 1BJB, 1BJC, 1BRC, 1CA0, 1HZ3, 1IYT, 1MWP, 1OWT, 1QCM, 1QWP, 1QXC, 1QYT, 1TAW, 1TKN, 1UO7, 1UO8, 1UOA, 1UOI, 1X11, 1Z0Q, 1ZE7, 1ZE9, 1ZJD, 2BEG, 2BOM, 2BP4, 2FJZ, 2FK1, 2FK2, 2FK3, 2FKL, 2FMA, 2G47, 2IPU, 2LFM, 2LLM, 2LMN, 2LMO, 2LMP, 2LMQ, 2LNQ, 2LOH, 2LP1, 2LZ3, 2LZ4, 2M4J, 2M9R, 2M9S, 2MGT, 2MJ1, 2MPZ, 2MVX, 2MXU, 2OTK, 2R0W, 2WK3, 2Y29, 2Y2A, 2Y3J, 2Y3K, 2Y3L, 3AYU, 3BAE, 3BKJ, 3DXC, 3DXD, 3DXE, 3GCI, 3IFL, 3IFN, 3IFO, 3IFP, 3JQ5, 3JQL, 3JTI, 3KTM, 3L33, 3L81, 3MOQ, 3MXC, 3MXY, 3NYJ, 3NYL, 3OVJ, 3OW9, 3SV1, 3U0T, 3UMH, 3UMI, 3UMK, 4HIX, 4JFN, 4M1C, 4MDR, 4NGE, 4OJF, 4ONF, 4ONG, 4PQD, 4PWQ
標識
代號	APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
擴展標識	遺傳學：104760 鼠基因：88059 同源基因：56379 ChEMBL: 2487 GeneCards: APP Gene
基因本體論描述 分子功能 · DNA binding · serine-type endopeptidase inhibitor activity · receptor binding · protein binding · heparin binding · peptidase activator activity · enzyme binding · acetylcholine receptor binding · identical protein binding · transition metal ion binding · PTB domain binding · growth factor receptor binding 細胞成分 · extracellular region · extracellular space · nuclear envelope lumen · cytoplasm · endosome · smooth endoplasmic reticulum · Golgi apparatus · cytosol · plasma membrane · integral component of plasma membrane · coated pit · cell-cell junction · cell surface · integral component of membrane · ER to Golgi transport vesicle · axon · platelet alpha granule lumen · neuromuscular junction · endosome lumen · trans-Golgi network membrane · ciliary rootlet · terminal bouton · dendritic spine · dendritic shaft · intracellular membrane-bounded organelle · receptor complex · membrane raft · apical part of cell · synapse · perinuclear region of cytoplasm · spindle midzone · extracellular exosome 生物過程 · suckling behavior · platelet degranulation · mRNA polyadenylation · regulation of translation · protein phosphorylation · cellular copper ion homeostasis · post-Golgi vesicle-mediated transport · endocytosis · response to oxidative stress · cell adhesion · regulation of epidermal growth factor-activated receptor activity · Notch signaling pathway · axonogenesis · blood coagulation · mating behavior · locomotory behavior · axon cargo transport · cholesterol metabolic process · adult locomotory behavior · visual learning · negative regulation of endopeptidase activity · positive regulation of peptidase activity · positive regulation of G2/M transition of mitotic cell cycle · axon midline choice point recognition · neuron remodeling · dendrite development · platelet activation · extracellular matrix organization · forebrain development · neuron projection development · ionotropic glutamate receptor signaling pathway · nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway · regulation of multicellular organism growth · regulation of protein binding · innate immune response · negative regulation of neuron differentiation · positive regulation of mitotic cell cycle · positive regulation of transcription from RNA polymerase II promoter · collateral sprouting in absence of injury · regulation of synapse structure or activity · neuromuscular process controlling balance · synaptic growth at neuromuscular junction · neuron apoptotic process · smooth endoplasmic reticulum calcium ion homeostasis · membrane organization Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	351	11820
Ensembl	ENSG00000142192	ENSMUSG00000022892
UniProt	P05067	P12023
mRNA序列	NM_000484	NM_001198823
蛋白序列	NP_000475	NP_001185752
基因位置	Chr 21: 25.88 – 26.17 Mb	Chr 16: 84.95 – 85.17 Mb
PubMed查詢	[1]	[2]