WNT974
| WNT974 | |
|---|---|
| |
| 別名 | LGK974 |
| 識別 | |
| CAS號 | 1243244-14-5 
|
| SMILES |
|
| 性質 | |
| 化學式 | C23H20N6O |
| 摩爾質量 | 396.44 g·mol−1 |
| 外觀 | 白色固體[1] |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
WNT974是一種有機化合物，化學式為C23H20N6O。它可以2-氨基吡啶-5-硼酸頻哪醇酯和2-碘吡嗪為原料，經多步反應製得。[1]它是一種Wnt信號抑制劑。[2][3]
參考文獻
[編輯]- ^ 1.0 1.1 Dai Cheng; Jun Liu; Dong Han; et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med. Chem. Lett. 2016, 7, 7, 676–680. doi:10.1021/acsmedchemlett.6b00038.
- ^ Shuying Xie; Wenbin Fu; Guangju Yu; et al. Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. Journal of Molecular Cell Biology, 2020. 12 (1): 42-54. doi:10.1093/jmcb/mjz023.
- ^ Jun Liu; Shifeng Pan; Mindy H. Hsieh; et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(50). doi:10.1073/pnas.1314239110.