胸腺基質淋巴細胞生成素

TSLP
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	4NN5、4NN6、4NN7
識別號
別名	TSLP；, thymic stromal lymphopoietin
外部ID	OMIM：607003 MGI：1855696 HomoloGene：81957 GeneCards：TSLP
相關疾病
	過敏性鼻炎
基因位置（人類）
染色體	5號染色體
終止	111,078,026 bp
基因位置（小鼠）
染色體	小鼠18號染色體
終止	32,952,850 bp
基因本體
分子功能	• 細胞因子活性; • interleukin-7 receptor binding;
細胞組分	• 細胞外空間; • 細胞外區域;
生物學過程	• regulation of signaling receptor activity; • interleukin-7-mediated signaling pathway; • positive regulation of cytokine-mediated signaling pathway; • positive regulation of cell population proliferation; • positive regulation of chemokine production; • positive regulation of interleukin-10 production; • positive regulation of interleukin-13 production; • positive regulation of interleukin-5 production; • positive regulation of interleukin-6 production; • positive regulation of mast cell activation; • positive regulation of tyrosine phosphorylation of STAT protein; • negative regulation of apoptotic process; • positive regulation of inflammatory response; • defense response to Gram-negative bacterium; • defense response to fungus; • antimicrobial humoral immune response mediated by antimicrobial peptide; • positive regulation of chemokine (C-C motif) ligand 1 production; • positive regulation of granulocyte colony-stimulating factor production; • positive regulation of receptor signaling pathway via STAT;
	Sources:Amigo / QuickGO
直系同源
	85480
	53603
	ENSG00000145777
	ENSMUSG00000024379
	Q969D9
	Q9JIE6
	NM_033035; NM_138551
	NM_021367
	NP_149024; NP_612561
	NP_067342
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胸腺基質淋巴細胞生成素（英語：Thymic stromal lymphopoietin，縮寫TSLP）是一種由人類基因 TSLP 編碼的蛋白質，是與白血球介素-2類似的細胞因子^[6]^[7]，其受體α亞基與白血球介素-7共用，β亞基由CRLF2基因編碼^[8]。

參考文獻

^ 與TSLP相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ebina-Shibuya R, Leonard WJ. Role of thymic stromal lymphopoietin in allergy and beyond. Nature Reviews. Immunology. January 2023, 23 (1): 24–37. PMC 9157039 . PMID 35650271. doi:10.1038/s41577-022-00735-y.
^ Tsilingiri K, Fornasa G, Rescigno M. Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cellular and Molecular Gastroenterology and Hepatology. March 2017, 3 (2): 174–182. PMC 5331833 . PMID 28275684. doi:10.1016/j.jcmgh.2017.01.005.
^ Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. American Journal of Respiratory Cell and Molecular Biology. August 2016, 55 (2): 264–274. PMC 4979369 . PMID 26934097. doi:10.1165/rcmb.2015-0380OC.

外部連結

PDB中UniProt可用的所有結構資訊之概述：Q969D9 (Thymic stromal lymphopoietin) 在PDBe-KB（英語：PDBe-KB）。

[1] 與TSLP相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ebina-Shibuya_2023-6] Ebina-Shibuya R, Leonard WJ. Role of thymic stromal lymphopoietin in allergy and beyond. Nature Reviews. Immunology. January 2023, 23 (1): 24–37. PMC 9157039 . PMID 35650271. doi:10.1038/s41577-022-00735-y.

[Tsilingiri_2017-7] Tsilingiri K, Fornasa G, Rescigno M. Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cellular and Molecular Gastroenterology and Hepatology. March 2017, 3 (2): 174–182. PMC 5331833 . PMID 28275684. doi:10.1016/j.jcmgh.2017.01.005.

[Piliponsky_2016-8] Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. American Journal of Respiratory Cell and Molecular Biology. August 2016, 55 (2): 264–274. PMC 4979369 . PMID 26934097. doi:10.1165/rcmb.2015-0380OC.

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