11β-羥孕酮
IUPAC名 (8S ,9S ,10R ,11S ,13S ,14S ,17S )-17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a ]phenanthren-3-one
別名
11β-OHP; 21-Deoxycorticosterone; 21-Desoxycorticosterone; 11β-Hydroxypregn-4-ene-3,20-dione
識別
CAS號
600-57-7
PubChem
101788
ChemSpider
91968
SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C
InChI
1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1
InChIKey
BFZHCUBIASXHPK-ATWVFEABSA-N
ChEBI
28247
KEGG
C05498
性質
化學式
C21 H30 O3
摩爾質量
330.46 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa) 下。
11β-羥孕酮 (英語:11β-Hydroxyprogesterone ,縮寫11β-OHP ,也稱為21-去氧皮質酮 ,21-deoxycorticosterone,或11β-羥基孕-4-烯-3,20-二酮 ,11β-hydroxypregn-4-ene-3,20-dione)是一種天然 內源 性甾體 激素和孕酮 的衍生物 ,是強效的鹽皮質激素 [ 1] 。11β-OHP主要由類固醇11-β-羥化酶 (CYP11B1)羥基化 孕酮生成[ 2] [ 3] ,也有少量由醛固酮合酶 (CYP11B2)合成[ 2] 。
^ Human Metabolome Database: Showing metabocard for 11b-Hydroxyprogesterone (HMDB04031) . hmdb.ca. [2016-12-16 ] . (原始內容存檔 於2016-12-21).
^ 2.0 2.1 Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW. Structural insights into aldosterone synthase substrate specificity and targeted inhibition . Molecular Endocrinology. February 2013, 27 (2): 315–24. PMC 5417327 . PMID 23322723 . doi:10.1210/me.2012-1287 .
^ van Rooyen D, Gent R, Barnard L, Swart AC. The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway. The Journal of Steroid Biochemistry and Molecular Biology. April 2018, 178 : 203–212. PMID 29277707 . doi:10.1016/j.jsbmb.2017.12.014 .