2-乙酰氧基-5-氟苯甲酸
| 2-乙酰氧基-5-氟苯甲酸 | |
|---|---|
| |
| 識別 | |
| CAS號 | 448-40-8 
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| SMILES |
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| 性質 | |
| 化學式 | C9H7FO4 |
| 摩爾質量 | 198.15 g·mol−1 |
| 熔點 | 130.5 °C（403.6 K）[1] |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
2-乙酰氧基-5-氟苯甲酸是一種有機化合物，化學式為C9H7O4F。
製備
[編輯]2-羥基-5-氟苯甲酸和乙酸酐反應，可以製得2-乙酰氧基-5-氟苯甲酸。[2][3]
性質
[編輯]2-乙酰氧基-5-氟苯甲酸和氯化亞碸在DMF的存在下於二氯甲烷溶劑中反應，可以得到2-乙酰氧基-5-氟苯甲酰氯。[4]它和2-氨基-5-硝基噻唑及PyBOP在一定條件下反應，生成2-羥基-5-氟-N-(5-硝基-2-噻唑氨基)苯甲酰胺。[2]
參考文獻
[編輯]- ^ Giuseppe Ciampa. Anhydrides of pharmacological interest. I. Synthesis and properties of symmetrical anhydrides of 2-acetoxy-5-halobenzoic acid（意大利文）. Annali di Chimica (Rome, Italy), 1964. 54 (10): 975-986. ISSN: 0003-4592.
- ^ 2.0 2.1 Joshua Odingo, Mai A. Bailey, Megan Files, Julie V. Early, Torey Alling, Devon Dennison, Julie Bowman, Suryakanta Dalai, Naresh Kumar, Jeffrey Cramer, Thierry Masquelin, Philip A. Hipskind, Tanya Parish. In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis. ACS Omega. 2017-09-30, 2 (9): 5873–5890 [2019-10-18]. ISSN 2470-1343. PMC 6044914
. PMID 30023755. doi:10.1021/acsomega.7b00892. （原始內容存檔於2021-05-25） （英語）.
- ^ Berkessel, Albrecht; Krueger, Mark; Kreuzer, Karl-Anton; Poll-Wolbeck, Simon. Preparation of phenylbenzoate derivatives and analogs for use as antitumor agents. PCT Int. Appl., 2015. WO 2015044177 A1.
- ^ Sakamoto, Kathleen Miho; Smith, Mark; Chae, Hee-Don; Mitton, Bryan; Cox, Nicholas Raymond. Inhibitors of CREB-CBP interaction for treatment of leukemia. PCT Int. Appl., 2017. WO 2017156489 A1.
