H1299細胞
H1299 (也稱為NCI-H1299[1]、CRL-5803) 是源自淋巴結的人類非小細胞肺癌細胞系，在研究中得到廣泛應用[2]。H1299細胞與其他永生細胞系一樣可以無限期分裂，並且因p53基因的純合子部分缺失，故而不表達腫瘤抑制基因p53蛋白，說明了它們的增殖傾向[3]。有研究指出這些細胞會分泌神經調節素B，但是不會分泌GRP[2]。
參考資料
[編輯]- ^ NCI-Navy Medical Oncology Branch cell line supplement.. Journal of cellular biochemistry. Supplement. 1996, 24: 1–291 [2019-11-29]. PMID 8965489.
- ^ 2.0 2.1 Giaccone, G; Battey, J; Gazdar, AF; Oie, H; Draoui, M; Moody, TW. Neuromedin B is present in lung cancer cell lines.. Cancer research. 1992-05-01, 52 (9 Suppl): 2732s–2736s [2019-11-29]. PMID 1563005.
- ^ Lin, DL; Chang, C. p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily.. The Journal of biological chemistry. 1996-06-21, 271 (25): 14649–52 [2019-11-29]. PMID 8663350. doi:10.1074/jbc.271.25.14649.