前列腺素D₂

前列腺素D2
	IUPAC名; 9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
识别
CAS号	41598-07-6
PubChem	448457
SMILES	CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O;
ChEBI	15555
MeSH	Prostaglandin+D2
IUPHAR配体	1891
性质
化学式	C20H32O5
摩尔质量	352.465 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

前列腺素D₂（PGD₂）是前列腺素的一种。^[1]^[2] 哺乳动物体内，大量的前列腺素只存在于脑部和肥大细胞中，其会影响过敏性疾病如哮喘等的发展。

前列腺素D₂的研究始于1989年，当时发现其为摄取烟酸后血管舒张（烟堿酸潮红）的原发性介质。^[3] 2012年发现局部的PGD₂提高会抑制头发生长，^[4] 研究指出这一现象与一个叫做GPR44的受体有关，后者因此成为了治疗雄激素性脱发的药物作用靶点，因此数种使用PGD₂的哮喘药都开始寻求减少其用量的方法。^[5]

参考文献

^ Saito S, Tsuda H, Michimata T. Prostaglandin D2 and reproduction. American Journal of Reproductive Immunology (New York, N.Y. : 1989). May 2002, 47 (5): 295–302 [2011-04-09]. PMID 12148545. doi:10.1034/j.1600-0897.2002.01113.x （美国英语）.
^ Pettipher R, Hansel TT. Antagonists of the prostaglandin D2 receptor CRTH2. Drug News & Perspectives. 2008, 21 (6): 317–22 [2011-04-09]. PMID 18836589. doi:10.1358/dnp.2008.21.6.1246831. （原始内容存档于2021-01-25）（美国英语）.
^ Morrow, JD; Parsons Wg, 3rd; Roberts Lj, 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. August 1989, 38 (2): 263–74. PMID 2475889.
^ Garza, Luis A.,; et al. Prostaglandin D₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia. Science Translational Medicine. 2012-03-21, 4 (126): 126ra34–126ra34 [2012-03-22]. ISSN 1946-6234. PMC 3319975 . PMID 22440736. doi:10.1126/scitranslmed.3003122. （原始内容存档于2020-11-18）.
^ Clues to the cause of male pattern baldness. Nature magazine (News and Comments). [2014-05-02]. （原始内容存档于2020-11-12）.

[pmid12148545-1] Saito S, Tsuda H, Michimata T. Prostaglandin D2 and reproduction. American Journal of Reproductive Immunology (New York, N.Y. : 1989). May 2002, 47 (5): 295–302 [2011-04-09]. PMID 12148545. doi:10.1034/j.1600-0897.2002.01113.x （美国英语）.

[pmid18836589-2] Pettipher R, Hansel TT. Antagonists of the prostaglandin D2 receptor CRTH2. Drug News & Perspectives. 2008, 21 (6): 317–22 [2011-04-09]. PMID 18836589. doi:10.1358/dnp.2008.21.6.1246831. （原始内容存档于2021-01-25）（美国英语）.

[3] Morrow, JD; Parsons Wg, 3rd; Roberts Lj, 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. August 1989, 38 (2): 263–74. PMID 2475889.

[Garza_et_al_2012-4] Garza, Luis A.,; et al. Prostaglandin D₂ Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia. Science Translational Medicine. 2012-03-21, 4 (126): 126ra34–126ra34 [2012-03-22]. ISSN 1946-6234. PMC 3319975 . PMID 22440736. doi:10.1126/scitranslmed.3003122. （原始内容存档于2020-11-18）.

[garza_nature_article-5] Clues to the cause of male pattern baldness. Nature magazine (News and Comments). [2014-05-02]. （原始内容存档于2020-11-12）.

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