组蛋白脱乙酰酶抑制剂
组蛋白脱乙酰酶抑制剂(英语：HDAC inhibitor，简写HDI或HDAC抑制剂)是一种透过抑制身体内组蛋白脱乙酰酶功能的药物类别，亦存在于胎儿及花椒内。现时有健康食品生产商建议透过进食花椒油而达至防癌的功效。
现时医学界有研究透过“组蛋白脱乙酰酶抑制剂”来治疗癌症[1]及神经退行性疾病(neurodegenerative diseases)。这些抑制剂的具体机制，例如有关的化合物如何达到有关的功效，到现在还未清楚。不过，有关文献亦有提出可能的表观遗传学途径[2] Richon et al.[3]发现HDAC抑制剂可以透过引导p21 (WAF1)来调节p53的肿瘤抑制功能[4]。对于 HDAC 抑制剂如何调控基因表达 ，目前已有比较大的进展。持续的研究 HDAC 抑制剂的调节基因机制，将快速促进新药设计及生物标记的鉴定 [5]。
参考
[编辑]- ^ Marks PA, Dokmanovic M. Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert opinion on investigational drugs. 2005, 14 (12): 1497–511. PMID 16307490. doi:10.1517/13543784.14.12.1497.
- ^ Claude Monneret. Histone deacetylase inhibitors for epigenetic therapy of cancer. Anticancer Drugs. April 2007, 18: 363–70.
- ^ Richon VM, Sandhoff TW, Rifkind RA, Marks PA. AUG 29 2000. "Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation." Proceedings of the National Academy of Sciences of the United States of America 97(18):10014-10019.
- ^ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. NOV 19 1993. "WAF1, a potential mediator of p53 tumor suppression." Cell 75(4):817-25.
- ^ Chueh, Anderly C.; Tse, Janson W.T.; Tögel, Lars; Mariadason, John M. Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells. Antioxidants & Redox Signaling. 2014-02-10, 23 (1): 66–84. ISSN 1523-0864. PMC 4492771
. PMID 24512308. doi:10.1089/ars.2014.5863.
