颗粒溶素 （英语：Granulysin ，又译为“颗粒溶解素”）是一种由细胞毒性T细胞 （CD8阳性 T细胞）在接触被感染的细胞时释放的物质。其功能为通过靶细胞的膜上形成的小孔，从而诱导靶细胞凋亡 ，另外也与抗微生物相关[1]
颗粒溶素是一种能产生细胞溶解 和炎症反应 的分子，最早通过抑制消减杂交 寻找在人细胞毒性T细胞激活3–5天时表达的基因发现。颗粒溶素会与具有穿孔能力的穿孔素 和颗粒酶 形成溶细胞颗粒。颗粒溶素具有广谱的抗微生物 功能，能杀伤结核杆菌 、疟原虫 等，甚至能杀伤一些肿瘤。一系列源自颗粒溶素的氨基酸序列的多肽 能作为潜在的抗细菌药 。
颗粒溶素最近被认为与史蒂芬斯－强森综合症 的发生发展有关。
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^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000115523 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
. PMID 18310138. doi:10.1093/jac/dkn058.