KLF4

KLF4
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2WBS、2WBU、4M9E
识别号
别名	KLF4；, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
外部ID	OMIM：602253 MGI：1342287 HomoloGene：3123 GeneCards：KLF4
基因位置（人类）
染色体	9号染色体
终止	107,490,482 bp
基因位置（小鼠）
染色体	小鼠4号染色体
终止	55,532,466 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • sequence-specific DNA binding; • beta-catenin binding; • phosphatidylinositol 3-kinase regulator activity; • DNA结合转录因子活性; • 锌离子结合; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • 核心启动子近端区域序列特异性DNA结合; • 金属离子结合; • RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; • 血浆蛋白结合; • nucleic acid binding; • double-stranded DNA binding; • promoter-specific chromatin binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription coregulator binding; • histone deacetylase binding;
细胞组分	• 细胞质; • 转录调节复合物; • 核质; • 染色质; • 细胞核;
生物学过程	• negative regulation of chemokine (C-X-C motif) ligand 2 production; • epidermal cell differentiation; • cellular response to retinoic acid; • negative regulation of protein kinase B signaling; • negative regulation of muscle hyperplasia; • 平滑肌细胞增殖的负调控; • positive regulation of protein metabolic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of axon regeneration; • cellular response to peptide; • regulation of transcription, DNA-templated; • positive regulation of hemoglobin biosynthetic process; • response to retinoic acid; • somatic stem cell population maintenance; • cellular response to laminar fluid shear stress; • regulation of transcription by RNA polymerase II; • 细胞分化; • epidermis morphogenesis; • positive regulation of nitric oxide biosynthetic process; • cellular response to growth factor stimulus; • cellular response to organic cyclic compound; • post-embryonic hemopoiesis; • negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • response to organic substance; • negative regulation of gene expression; • negative regulation of response to cytokine stimulus; • transcription, DNA-templated; • negative regulation of DNA-binding transcription factor activity; • negative regulation of phosphatidylinositol 3-kinase signaling; • stem cell population maintenance; • negative regulation of cell migration involved in sprouting angiogenesis; • positive regulation of gene expression; • negative regulation of cell migration; • regulation of cell population proliferation; • post-embryonic camera-type eye development; • regulation of phosphatidylinositol 3-kinase activity; • positive regulation of telomerase activity; • canonical Wnt signaling pathway; • negative regulation of ERK1 and ERK2 cascade; • regulation of cell differentiation; • mesodermal cell fate determination; • negative regulation of heterotypic cell-cell adhesion; • negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • cellular response to cycloheximide; • negative regulation of inflammatory response; • fat cell differentiation; • positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • cellular response to hydrogen peroxide; • negative regulation of leukocyte adhesion to arterial endothelial cell; • positive regulation of core promoter binding; • cellular response to leukemia inhibitory factor; • negative regulation of angiogenesis; • pri-miRNA transcription by RNA polymerase II; • negative regulation of G1/S transition of mitotic cell cycle; • positive regulation of transcription, DNA-templated; • positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
直系同源
	9314
	16600
	ENSG00000136826
	ENSMUSG00000003032
	O43474
	Q60793
	NM_001314052; NM_004235
	NM_010637
	NP_001300981; NP_004226
	NP_034767
	维基数据
查看/编辑人类	查看/编辑小鼠

Kruppel样因子4（英语：Kruppel-like factor 4，缩写KLF4）或肠富集Krüppel样因子（英语：gut-enriched Krüppel-like factor，缩写GKLF）是锌指转录因子KLF家族的一个成员，后者属于一个较大的SP1（英语：Sp1 transcription factor）样转录因子家族^[5]^[6]^[7]。KLF4参与细胞增殖、细胞分化、细胞凋亡和体细胞重编程（英语：Reprogramming）的调节。有证据表明KLF4在包括大肠癌在内的一些癌症中是肿瘤抑制基因^[8]。与KLF2（英语：KLF2）类似，它在C端有三个C2H2型锌指^[6]。它有两个核定位序列指引它定位于细胞核内^[9]。在胚胎干细胞(ESCs)和间充质干细胞(MSCs)中KLF4是显示多能化的很好标记。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136826 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000003032 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.
^ ^6.0 ^6.1 Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176 . PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.
^ Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296 . PMID 12620113. doi:10.1186/gb-2003-4-2-206.
^ El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599 . PMID 23919723. doi:10.1186/1476-4598-12-89.
^ Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085 . PMID 9218496. doi:10.1074/jbc.272.29.18504.

外部链接

KLF4引用了美国国家医学图书馆提供的数据，这些数据属于公共领域。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136826 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000003032 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. Journal of Cellular Physiology. August 2001, 188 (2): 143–60. PMID 11424081. doi:10.1002/jcp.1111.

[pmid11137451-6] 6.0 ^6.1 Dang DT, Pevsner J, Yang VW. The biology of the mammalian Krüppel-like family of transcription factors. The International Journal of Biochemistry & Cell Biology. November 2000, 32 (11–12): 1103–21. PMC 2754176 . PMID 11137451. doi:10.1016/s1357-2725(00)00059-5.

[7] Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biology. 2003, 4 (2): 206. PMC 151296 . PMID 12620113. doi:10.1186/gb-2003-4-2-206.

[8] El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Molecular Cancer. August 2013, 12: 89. PMC 3750599 . PMID 23919723. doi:10.1186/1476-4598-12-89.

[9] Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. The Journal of Biological Chemistry. July 1997, 272 (29): 18504–7. PMC 2268085 . PMID 9218496. doi:10.1074/jbc.272.29.18504.

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