环肽

环肽（cyclic peptide）是包含环状键序列的多肽链。这可以通过肽的氨基和羧基末端之间的连接来实现，例如在环孢素中。氨基端和侧链之间的连接，例如杆菌肽中的连接；羧基末端和侧链，例如在粘菌素中；或两个侧链或更复杂的排列方式，例如鹅膏毒肽。在自然界中已经发现了许多环肽，并且在实验室中已经合成了许多其他环肽。它们的长度范围从仅两个到数百个氨基酸残基。在自然界中，它们通常具有抗微生物或毒性；在医学上，它们有多种应用，例如用作抗生素和免疫抑制剂^[1]。薄层色谱法（Thin-Layer Chromatography , 缩写：TLC）是检测生物质粗提物中环肽的一种便捷方法^[2]。

生物合成

植物中的环肽是通过两步过程合成的。线性肽链的翻译，以及随后通过蛋白酶样酶的活性或其他方式形成环状结构的方法^[3]^[4]^[5]。

参考文献

^ Jensen, Knud. Peptide and Protein Design for Biopharmaceutical Applications. John Wiley & Sons. 2009-09-01 [2019-10-08]. ISBN 9780470749715. （原始内容存档于2017-10-23）（英语）.
^ Wenyan, Xu; Jun, Tang; Changjiu, Ji; Wenjun, He; Ninghua, Tan. Application of a TLC chemical method to detection of cyclotides in plants. Science Bulletin. 2008, 53 (11): 1671–1674. doi:10.1007/s11434-008-0178-8.
^ Barber, Carla J. S.; Pujara, Pareshkumar T.; Reed, Darwin W.; Chiwocha, Shiela; Zhang, Haixia; Covello, Patrick S. The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme. Journal of Biological Chemistry. 2013, 288 (18): 12500–12510. PMC 3642298 . PMID 23486480. doi:10.1074/jbc.M112.437947.
^ Wenyan Xu; et al. Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases. Acta Biochimica et Biophysica Sinica. 2011, 43 (10): 757–762. PMC 3180235 . PMID 21764803. doi:10.1093/abbs/gmr062.
^ Wenyan Xu; et al. Plant Cyclopeptides and Possible Biosynthetic Mechanisms.

外部链接

Cybase （页面存档备份，存于互联网档案馆）
医学主题词表（MeSH）：Cyclic+Peptides

[1] Jensen, Knud. Peptide and Protein Design for Biopharmaceutical Applications. John Wiley & Sons. 2009-09-01 [2019-10-08]. ISBN 9780470749715. （原始内容存档于2017-10-23）（英语）.

[2] Wenyan, Xu; Jun, Tang; Changjiu, Ji; Wenjun, He; Ninghua, Tan. Application of a TLC chemical method to detection of cyclotides in plants. Science Bulletin. 2008, 53 (11): 1671–1674. doi:10.1007/s11434-008-0178-8.

[3] Barber, Carla J. S.; Pujara, Pareshkumar T.; Reed, Darwin W.; Chiwocha, Shiela; Zhang, Haixia; Covello, Patrick S. The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme. Journal of Biological Chemistry. 2013, 288 (18): 12500–12510. PMC 3642298 . PMID 23486480. doi:10.1074/jbc.M112.437947.

[4] Wenyan Xu; et al. Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases. Acta Biochimica et Biophysica Sinica. 2011, 43 (10): 757–762. PMC 3180235 . PMID 21764803. doi:10.1093/abbs/gmr062.

[5] Wenyan Xu; et al. Plant Cyclopeptides and Possible Biosynthetic Mechanisms.

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