维甲酸诱导基因-I

DDX58
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2LWD、2LWE、2QFB、2QFD、2RMJ、2YKG、3LRN、3LRR、3NCU、3OG8、3ZD6、3ZD7、4AY2、4BPB、4NQK、4ON9、4P4H、5E3H、5F98、5F9F、5F9H
识别号
别名	DDX58；, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIGI, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58, RIG1
外部ID	OMIM：609631 MGI：2442858 HomoloGene：32215 GeneCards：DDX58
基因位置（人类）
染色体	9号染色体
终止	32,526,208 bp
基因位置（小鼠）
染色体	小鼠4号染色体
终止	40,239,828 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 核苷酸结合; • helicase activity; • 锌离子结合; • 金属离子结合; • 血浆蛋白结合; • single-stranded RNA binding; • 相同蛋白质结合; • RNA binding; • double-stranded RNA binding; • double-stranded DNA binding; • 水解酶活性; • ATP结合; • nucleic acid binding; • 泛素蛋白连接酶结合;
细胞组分	• 细胞质; • cell projection; • 膜; • 双细胞紧密连接; • 细胞膜; • ruffle membrane; • 细胞连接; • actin cytoskeleton; • 细胞骨架; • 细胞质基质;
生物学过程	• regulation of cell migration; • response to exogenous dsRNA; • positive regulation of interferon-alpha production; • immune system process; • response to virus; • cytoplasmic pattern recognition receptor signaling pathway in response to virus; • positive regulation of gene expression; • positive regulation of granulocyte macrophage colony-stimulating factor production; • positive regulation of interleukin-8 production; • positive regulation of interleukin-6 production; • negative regulation of type I interferon production; • detection of virus; • viral process; • 先天免疫系统; • positive regulation of transcription by RNA polymerase II; • RIG-I signaling pathway; • regulation of type III interferon production; • positive regulation of defense response to virus by host; • positive regulation of interferon-beta production; • protein deubiquitination; • positive regulation of response to cytokine stimulus; • cellular response to exogenous dsRNA; • defense response to virus; • positive regulation of DNA-binding transcription factor activity; • positive regulation of myeloid dendritic cell cytokine production;
	Sources:Amigo / QuickGO
直系同源
	23586
	230073
	ENSG00000107201
	ENSMUSG00000040296
	O95786
	Q6Q899
	NM_014314
	NM_172689
	NP_055129
	NP_766277
	维基数据
查看/编辑人类	查看/编辑小鼠

维甲酸诱导基因-I^[5]（RIG-I，retinoic acid-inducible gene I）是脊椎动物细胞质中的一种模式识别受体（PRR），结构上属于DExD/H-box（英语：DExD/H box proteins）类RNA解旋酶^[6]^[7]^[8]，在人类基因组中由DDX58基因编码^[9]，其N端有两个CARD结构域（英语：CARD domain），C端则可与RNA结合，为先天免疫反应中的重要蛋白^[6]^[7]。

RIG-I平时处于灭活状态，在细胞被西尼罗河病毒、黄热病毒（英语：Flavivirus）、日本脑炎病毒、甲型流感病毒、仙台病毒与冠状病毒等RNA病毒感染后^[6]^[10]，RIG-I可与病毒的双股RNA（dsRNA）结合而被激活，接着即可以CARD结构域和线粒体外膜上的线粒体抗病毒信号蛋白（英语：Mitochondrial antiviral-signaling protein）（MAVS）结合^[7]，启动第一型干扰素（英语：Interferon type I）（IFN I）途径的免疫反应^[6]，后者可阻止病毒扩散、造成发炎反应以及协助激活后天免疫^[11]。除识别病毒RNA外，在不同癌细胞中RIG-I还能启动其他反应，包括促进或抑制肿瘤增殖（因肿瘤类型而异）、激活B细胞、影响细胞分化等^[12]。有些无脊椎动物（牡蛎）也具有和RIG-I与MAVS同源的蛋白，且可能也有抗病毒的免疫功能^[13]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000107201 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000040296 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 存档副本. [2021-07-06]. （原始内容存档于2021-07-09）.
^ ^6.0 ^6.1 ^6.2 ^6.3 Kell AM, Gale M. RIG-I in RNA virus recognition. Virology. May 2015,. 479-480: 110–21. PMC 4424084 . PMID 25749629. doi:10.1016/j.virol.2015.02.017.
^ ^7.0 ^7.1 ^7.2 Brisse M, Ly H. Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. Frontiers in Immunology. 2019, 10: 1586. PMC 6652118 . PMID 31379819. doi:10.3389/fimmu.2019.01586 （英语）.
^ Xu XX, Wan H, Nie L, Shao T, Xiang LX, Shao JZ. RIG-I: a multifunctional protein beyond a pattern recognition receptor. Protein & Cell. March 2018, 9 (3): 246–253. PMC 5829270 . PMID 28593618. doi:10.1007/s13238-017-0431-5.
^ DDX58 DExD/H-box helicase 58 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2020-02-29]. （原始内容存档于2021-04-24）.
^ Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, et al. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Journal of Virology. February 2011, 85 (3): 1224–36. PMC 3020501 . PMID 21084468. doi:10.1128/JVI.01635-10.
^ Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nature Reviews. Immunology. January 2014, 14 (1): 36–49. PMC 4084561 . PMID 24362405. doi:10.1038/nri3581.
^ Xu XX, Wan H, Nie L, Shao T, Xiang LX, Shao JZ. RIG-I: a multifunctional protein beyond a pattern recognition receptor.. Protein Cell. 2018, 9 (3): 246–253. PMC 5829270 . PMID 28593618. doi:10.1007/s13238-017-0431-5.
^ Huang B, Zhang L, Du Y, Xu F, Li L, Zhang G. Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.. Sci Rep. 2017, 7 (1): 8217. PMC 5557890 . PMID 28811654. doi:10.1038/s41598-017-08566-x.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000107201 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000040296 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] 存档副本. [2021-07-06]. （原始内容存档于2021-07-09）.

[:03-6] 6.0 ^6.1 ^6.2 ^6.3 Kell AM, Gale M. RIG-I in RNA virus recognition. Virology. May 2015,. 479-480: 110–21. PMC 4424084 . PMID 25749629. doi:10.1016/j.virol.2015.02.017.

[:13-7] 7.0 ^7.1 ^7.2 Brisse M, Ly H. Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5. Frontiers in Immunology. 2019, 10: 1586. PMC 6652118 . PMID 31379819. doi:10.3389/fimmu.2019.01586 （英语）.

[:2-8] Xu XX, Wan H, Nie L, Shao T, Xiang LX, Shao JZ. RIG-I: a multifunctional protein beyond a pattern recognition receptor. Protein & Cell. March 2018, 9 (3): 246–253. PMC 5829270 . PMID 28593618. doi:10.1007/s13238-017-0431-5.

[9] DDX58 DExD/H-box helicase 58 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2020-02-29]. （原始内容存档于2021-04-24）.

[:0-10] Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, et al. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Journal of Virology. February 2011, 85 (3): 1224–36. PMC 3020501 . PMID 21084468. doi:10.1128/JVI.01635-10.

[:5-11] Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nature Reviews. Immunology. January 2014, 14 (1): 36–49. PMC 4084561 . PMID 24362405. doi:10.1038/nri3581.

[pmid28593618-12] Xu XX, Wan H, Nie L, Shao T, Xiang LX, Shao JZ. RIG-I: a multifunctional protein beyond a pattern recognition receptor.. Protein Cell. 2018, 9 (3): 246–253. PMC 5829270 . PMID 28593618. doi:10.1007/s13238-017-0431-5.

[pmid28811654-13] Huang B, Zhang L, Du Y, Xu F, Li L, Zhang G. Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates.. Sci Rep. 2017, 7 (1): 8217. PMC 5557890 . PMID 28811654. doi:10.1038/s41598-017-08566-x.

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