4-甲氧基苯甲腈

4-甲氧基苯甲腈
别名	4-氰基苯甲醚; 对甲氧基苯甲腈; 对氰基苯甲醚
识别
CAS号	874-90-8
SMILES	COc1ccc(C#N)cc1;
性质
化学式	C8H7NO
摩尔质量	133.15 g·mol−1
密度	1.297 g·cm−3（100 K）
熔点	59—61 °C（332—334 K）
沸点	256—257 °C（529—530 K）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-甲氧基苯甲腈是一种有机化合物，化学式为C₈H₇NO。它可由4-甲氧基苯甲醇的氨氧化反应制得；^[4]4-甲氧基苯甲醛在催化下和盐酸羟胺反应，也能得到4-甲氧基苯甲腈。^[5]在催化下，它和氨硼烷或氢气反应，可以得到二(4-甲氧基苄基)胺。^[6]^[7]

参考文献

^ M. J. Gerald Lesley, Mark R. Pineau, Allen D. Hunter, Matthias Zeller. p -Anisolecarbonitrile. Acta Crystallographica Section E Structure Reports Online. 2004-11-15, 60 (11): o1937–o1938 [2021-12-22]. ISSN 1600-5368. doi:10.1107/S1600536804022913. （原始内容存档于2021-12-22）.
^ Abdol R. Hajipour, Kazem Karami, Ghazal Tavakoli, Azade Pirisedigh. An efficient palladium catalytic system for microwave assisted cyanation of aryl halides. Journal of Organometallic Chemistry. 2011-02, 696 (4): 819–824 [2021-12-22]. doi:10.1016/j.jorganchem.2010.10.002. （原始内容存档于2018-06-27）（英语）.
^ Suvorov, B. V.; Vorob'ev, P. B.; Erzhanov, A. A.; Li, L. V. Synthesis of 4-methoxy- and 4-hydroxybenzonitrile by gas-phase ammonolysis of methyl 4-methoxybenzoate. Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1991. 64 (1): 227-229. ISSN 0044-4618. CODEN ZPKHAB.
^ Sun, Kang-kang; Sun, Jia-lin; Lu, Guo-Ping; Cai, Chun. Enhanced catalytic activity of cobalt nanoparticles encapsulated with an N-doped porous carbon shell derived from hollow ZIF-8 for efficient synthesis of nitriles from primary alcohols in water. Green Chemistry (Royal Society of Chemistry (RSC)). 2019, 21 (16): 4334–4340. ISSN 1463-9262. doi:10.1039/c9gc01893j.
^ Shashank, M; Bhojya Naik, H S; Shashikanth, J; Nizam, Aatika; Nagaraju, G. Green synthesis of zirconium phosphate by combustion method: photocatalytic application and microwave-assisted catalytic conversion of aldehyde to nitriles. Bulletin of Materials Science (Springer Science and Business Media LLC). 2021-10-16, 44 (4). ISSN 0250-4707. doi:10.1007/s12034-021-02555-7.
^ Rongxiu Guo, Xinyue Zhang, Ze-Nan Hu, Hong Li, Jianyi Gao, Jiaping Wang, Qionglin Liang, Xiaodong Li, Dun Niu, Hong-bin Sun. A hollow in hollow nanoreactor of H-PtCu@SiO2 for the selective transfer hydrogenation. Chemical Engineering Journal. 2021-12, 425: 131417 [2021-12-22]. doi:10.1016/j.cej.2021.131417 （英语）.
^ Hengwei Wang, Qiquan Luo, Wei Liu, Yue Lin, Qiaoqiao Guan, Xusheng Zheng, Haibin Pan, Junfa Zhu, Zhihu Sun, Shiqiang Wei, Jinlong Yang, Junling Lu. Quasi Pd1Ni single-atom surface alloy catalyst enables hydrogenation of nitriles to secondary amines. Nature Communications. 2019-12, 10 (1) [2021-12-22]. ISSN 2041-1723. PMC 6825208 . PMID 31676812. doi:10.1038/s41467-019-12993-x. （原始内容存档于2021-12-22）（英语）.

[1] M. J. Gerald Lesley, Mark R. Pineau, Allen D. Hunter, Matthias Zeller. p -Anisolecarbonitrile. Acta Crystallographica Section E Structure Reports Online. 2004-11-15, 60 (11): o1937–o1938 [2021-12-22]. ISSN 1600-5368. doi:10.1107/S1600536804022913. （原始内容存档于2021-12-22）.

[2] Abdol R. Hajipour, Kazem Karami, Ghazal Tavakoli, Azade Pirisedigh. An efficient palladium catalytic system for microwave assisted cyanation of aryl halides. Journal of Organometallic Chemistry. 2011-02, 696 (4): 819–824 [2021-12-22]. doi:10.1016/j.jorganchem.2010.10.002. （原始内容存档于2018-06-27）（英语）.

[3] Suvorov, B. V.; Vorob'ev, P. B.; Erzhanov, A. A.; Li, L. V. Synthesis of 4-methoxy- and 4-hydroxybenzonitrile by gas-phase ammonolysis of methyl 4-methoxybenzoate. Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1991. 64 (1): 227-229. ISSN 0044-4618. CODEN ZPKHAB.

[4] Sun, Kang-kang; Sun, Jia-lin; Lu, Guo-Ping; Cai, Chun. Enhanced catalytic activity of cobalt nanoparticles encapsulated with an N-doped porous carbon shell derived from hollow ZIF-8 for efficient synthesis of nitriles from primary alcohols in water. Green Chemistry (Royal Society of Chemistry (RSC)). 2019, 21 (16): 4334–4340. ISSN 1463-9262. doi:10.1039/c9gc01893j.

[5] Shashank, M; Bhojya Naik, H S; Shashikanth, J; Nizam, Aatika; Nagaraju, G. Green synthesis of zirconium phosphate by combustion method: photocatalytic application and microwave-assisted catalytic conversion of aldehyde to nitriles. Bulletin of Materials Science (Springer Science and Business Media LLC). 2021-10-16, 44 (4). ISSN 0250-4707. doi:10.1007/s12034-021-02555-7.

[6] Rongxiu Guo, Xinyue Zhang, Ze-Nan Hu, Hong Li, Jianyi Gao, Jiaping Wang, Qionglin Liang, Xiaodong Li, Dun Niu, Hong-bin Sun. A hollow in hollow nanoreactor of H-PtCu@SiO2 for the selective transfer hydrogenation. Chemical Engineering Journal. 2021-12, 425: 131417 [2021-12-22]. doi:10.1016/j.cej.2021.131417 （英语）.

[7] Hengwei Wang, Qiquan Luo, Wei Liu, Yue Lin, Qiaoqiao Guan, Xusheng Zheng, Haibin Pan, Junfa Zhu, Zhihu Sun, Shiqiang Wei, Jinlong Yang, Junling Lu. Quasi Pd1Ni single-atom surface alloy catalyst enables hydrogenation of nitriles to secondary amines. Nature Communications. 2019-12, 10 (1) [2021-12-22]. ISSN 2041-1723. PMC 6825208 . PMID 31676812. doi:10.1038/s41467-019-12993-x. （原始内容存档于2021-12-22）（英语）.

[1]

[2]

[3]

[4]

[5]

[6]

[7]