ARH-77

ARH-77 (亦称ATCC CRL-1621) 是人类浆细胞白血病细胞系^[1]，最初是由一位33岁白人女性 IgG型浆细胞白血病（英语：Plasma cell leukemia）患者的外周血中分离出来的。该细胞是感染人类疱疹病毒第四型的B淋巴细胞^[2]，并且表达CD11a（英语：Integrin alpha L）、CD19及CD20（英语：CD20）等抗原，但是不会表达跨膜蛋白CD38（英语：CD38）。有研究发现诱导MGC-803胃癌细胞凋亡的迷迭香酸（英语：Rosmarinic acid）^[3]会上调ARH-77细胞CD95的信使核糖核酸和蛋白水平，从而形成死亡诱导信号复合体（英语：Death-inducing signaling complex），使细胞因级联反应而凋亡^[4]，抑制ARH-77细胞的增殖。同时又有研究指出姜黄素会通过激活外源性凋亡途径^[5]令ARH-77细胞的凋亡率明显地增加，细胞出现核固缩（英语：Pyknosis）及胞体变小的现象，并且呈现浓度依赖性。

参考资料

^ Burk, KH; Drewinko, B; Turjillo, JM; Ahearn, MJ. Establishment of a human plasma cell line in vitro.. Cancer research. 1978-08, 38 (8): 2508–13 [2019-12-05]. PMID 566614.
^ Drewinko, B; Mars, W; Minowada, J; Burk, KH; Trujillo, JM. ARH-77, an established human IgG-producing myeloma cell line. I. Morphology, B-cell phenotypic marker profile, and expression of Epstein-Barr virus.. Cancer. 1984-11-01, 54 (9): 1883–92 [2019-12-05]. PMID 6090003. doi:10.1002/1097-0142(19841101)54:9<1883::aid-cncr2820540919>3.0.co;2-q.
^ Martinez-Lopez, J; Blade, J; Mateos, MV; Grande, C; Alegre, A; García-Laraña, J; Sureda, A; de la Rubia, J; Conde, E; Martinez, R; de Arriba, F; Viguria, MC; Besalduch, J; Cabrera, R; Gonzalez-San Miguel, JD; Guzman-Zamudio, JL; Gomez del Castillo, MC; Moraleda, JM; García-Ruiz, JC; San Miguel, J; Lahuerta, JJ; Grupo Español de, MM.; Programa para el Estudio de la Terapé utica en Hemopatía, Maligna. Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.. Blood. 2011-07-21, 118 (3): 529–534 [2019-12-05]. PMID 21482708. doi:10.1182/blood-2011-01-332320.
^ Krantic, S; Mechawar, N; Reix, S; Quirion, R. Apoptosis-inducing factor: a matter of neuron life and death.. Progress in neurobiology. 2007-02, 81 (3): 179–196 [2019-12-05]. PMID 17267093. doi:10.1016/j.pneurobio.2006.12.002.
^ Takeda, K; Stagg, J; Yagita, H; Okumura, K; Smyth, MJ. Targeting death-inducing receptors in cancer therapy.. Oncogene. 2007-05-28, 26 (25): 3745–57 [2019-12-05]. PMID 17530027. doi:10.1038/sj.onc.1210374.

外部链接

Cellosaurus entry for ARH-77（页面存档备份，存于互联网档案馆）

[1] Burk, KH; Drewinko, B; Turjillo, JM; Ahearn, MJ. Establishment of a human plasma cell line in vitro.. Cancer research. 1978-08, 38 (8): 2508–13 [2019-12-05]. PMID 566614.

[2] Drewinko, B; Mars, W; Minowada, J; Burk, KH; Trujillo, JM. ARH-77, an established human IgG-producing myeloma cell line. I. Morphology, B-cell phenotypic marker profile, and expression of Epstein-Barr virus.. Cancer. 1984-11-01, 54 (9): 1883–92 [2019-12-05]. PMID 6090003. doi:10.1002/1097-0142(19841101)54:9<1883::aid-cncr2820540919>3.0.co;2-q.

[3] Martinez-Lopez, J; Blade, J; Mateos, MV; Grande, C; Alegre, A; García-Laraña, J; Sureda, A; de la Rubia, J; Conde, E; Martinez, R; de Arriba, F; Viguria, MC; Besalduch, J; Cabrera, R; Gonzalez-San Miguel, JD; Guzman-Zamudio, JL; Gomez del Castillo, MC; Moraleda, JM; García-Ruiz, JC; San Miguel, J; Lahuerta, JJ; Grupo Español de, MM.; Programa para el Estudio de la Terapé utica en Hemopatía, Maligna. Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.. Blood. 2011-07-21, 118 (3): 529–534 [2019-12-05]. PMID 21482708. doi:10.1182/blood-2011-01-332320.

[4] Krantic, S; Mechawar, N; Reix, S; Quirion, R. Apoptosis-inducing factor: a matter of neuron life and death.. Progress in neurobiology. 2007-02, 81 (3): 179–196 [2019-12-05]. PMID 17267093. doi:10.1016/j.pneurobio.2006.12.002.

[5] Takeda, K; Stagg, J; Yagita, H; Okumura, K; Smyth, MJ. Targeting death-inducing receptors in cancer therapy.. Oncogene. 2007-05-28, 26 (25): 3745–57 [2019-12-05]. PMID 17530027. doi:10.1038/sj.onc.1210374.

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