模板:PBB/5649

Reelin
Reelin
	络丝蛋白第三重复域的晶体结构
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2ddu, 2e26
标识
代号	RELN; LIS2; PRO1598; RL
扩展标识	遗传学：600514 鼠基因：103022 同源基因：3699 GeneCards: RELN Gene
EC编号	3.4.21.-
基因本体论描述
分子功能	· protein serine/threonine/tyrosine kinase activity; · serine-type peptidase activity; · metal ion binding; · lipoprotein particle receptor binding; · very-low-density lipoprotein particle receptor binding;
细胞成分	· proteinaceous extracellular matrix; · extracellular space; · cytoplasm; · dendrite;
生物过程	· cell morphogenesis involved in differentiation; · neuron migration; · proteolysis; · cell adhesion; · axon guidance; · central nervous system development; · brain development; · long-term memory; · associative learning; · glial cell differentiation; · positive regulation of neuron projection development; · positive regulation of phosphatidylinositol 3-kinase cascade; · dendrite development; · peptidyl-tyrosine phosphorylation; · spinal cord patterning; · ventral spinal cord development; · hippocampus development; · cerebral cortex tangential migration; · positive regulation of TOR signaling cascade; · positive regulation of CREB transcription factor activity; · reelin-mediated signaling pathway; · positive regulation of protein kinase activity; · response to pain; · positive regulation of peptidyl-tyrosine phosphorylation; · regulation of behavior; · regulation of synaptic transmission; · positive regulation of small GTPase mediated signal transduction; · positive regulation of synaptic transmission, glutamatergic; · positive regulation of dendritic spine morphogenesis; · positive regulation of protein tyrosine kinase activity; · positive regulation of synapse maturation; · N-methyl-D-aspartate receptor clustering; · postsynaptic density protein 95 clustering; · receptor localization to synapse; · positive regulation of long-term synaptic potentiation; · regulation of N-methyl-D-aspartate selective glutamate receptor activity; · positive regulation of excitatory postsynaptic membrane potential; · positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	5649
Ensembl	ENSG00000189056
UniProt	P78509
mRNA序列	NM_005045
蛋白序列	NP_005036
基因位置	Chr 7:; 103.11 – 103.63 Mb
PubMed查询	[1]
	查; 论; 编;

参考资料

^ PDB 2ddu; Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J. Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J. August 2006, 25 (15): 3675–83. PMC 1538547 . PMID 16858396. doi:10.1038/sj.emboj.7601240.

[reelinstructure2006japan-1] PDB 2ddu; Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J. Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. EMBO J. August 2006, 25 (15): 3675–83. PMC 1538547 . PMID 16858396. doi:10.1038/sj.emboj.7601240.

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