骨質軟化

骨質軟化
骨質軟化
	膽鈣化醇（維生素D3）的缺乏是引起骨質軟化最常見的原因
類型	bone remodeling disease[*]、疾病
分類和外部資源
醫學專科	風濕病學
ICD-11	FB83.2
ICD-10	M83
ICD-9-CM	268.2
DiseasesDB	9351
MedlinePlus	000376
eMedicine	985510、412862
	[編輯此條目的維基數據]

骨質軟化（英語：Osteomalacia）又稱軟骨病，是一種因骨骼代謝障礙而引起的骨骼軟化疾病，引起骨骼代謝（英語：Bone remodeling）障礙的原因有人體缺乏磷酸鹽、鈣和維生素D，或是鈣的骨質吸收作用。兒童要是出現骨質疏鬆則稱為佝僂病，正因為如此，骨質疏鬆症這一稱呼常用於程度較輕的成人患者。骨質軟化的症狀和體徵有身體出現瀰漫性疼痛、肌肉無力和脆弱的骨骼^[1]^[2]^[3]^[4]^[5]。及時補充維生素D和鈣可以預防和治療骨質軟化^[6]。

參考文獻

^ Salmon, B; Bardet, C; Coyac, BR; Baroukh, B; Naji, J; Rowe, PS; Opsahl Vital, S; Linglart, A; Mckee, MD. Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth.. Connective Tissue Research. August 2014,. 55 Suppl 1: 79–82. PMID 25158186. doi:10.3109/03008207.2014.923864.
^ Boukpessi, T; Hoac, B; Coyac, BR; Leger, T; Garcia, C; Wicart, P; Whyte, MP; Glorieux, FH; Linglart, A. Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.. Bone. 21 November 2016, 95: 151–161. PMID 27884786. doi:10.1016/j.bone.2016.11.019.
^ Barros, NM; Hoac, B; Neves, RL; Addison, WN; Assis, DM; Murshed, M; Carmona, AK; McKee, MD. Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia.. Journal of Bone and Mineral Research. March 2013, 28 (3): 688–99. PMID 22991293. doi:10.1002/jbmr.1766.
^ McKee, MD; Hoac, B; Addison, WN; Barros, NM; Millán, JL; Chaussain, C. Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.. Periodontology 2000. October 2013, 63 (1): 102–22. PMC 3766584 . PMID 23931057. doi:10.1111/prd.12029.
^ Boukpessi, T; Gaucher, C; Léger, T; Salmon, B; Le Faouder, J; Willig, C; Rowe, PS; Garabédian, M; Meilhac, O. Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.. The American Journal of Pathology. August 2010, 177 (2): 803–12. PMC 2913338 . PMID 20581062. doi:10.2353/ajpath.2010.091231.
^ Longo, Dan L.; et al. Harrison's principles of internal medicine. 18th. New York: McGraw-Hill. 2012. ISBN 978-0-07174889-6.

[1] Salmon, B; Bardet, C; Coyac, BR; Baroukh, B; Naji, J; Rowe, PS; Opsahl Vital, S; Linglart, A; Mckee, MD. Abnormal osteopontin and matrix extracellular phosphoglycoprotein localization, and odontoblast differentiation, in X-linked hypophosphatemic teeth.. Connective Tissue Research. August 2014,. 55 Suppl 1: 79–82. PMID 25158186. doi:10.3109/03008207.2014.923864.

[2] Boukpessi, T; Hoac, B; Coyac, BR; Leger, T; Garcia, C; Wicart, P; Whyte, MP; Glorieux, FH; Linglart, A. Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.. Bone. 21 November 2016, 95: 151–161. PMID 27884786. doi:10.1016/j.bone.2016.11.019.

[3] Barros, NM; Hoac, B; Neves, RL; Addison, WN; Assis, DM; Murshed, M; Carmona, AK; McKee, MD. Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia.. Journal of Bone and Mineral Research. March 2013, 28 (3): 688–99. PMID 22991293. doi:10.1002/jbmr.1766.

[4] McKee, MD; Hoac, B; Addison, WN; Barros, NM; Millán, JL; Chaussain, C. Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.. Periodontology 2000. October 2013, 63 (1): 102–22. PMC 3766584 . PMID 23931057. doi:10.1111/prd.12029.

[5] Boukpessi, T; Gaucher, C; Léger, T; Salmon, B; Le Faouder, J; Willig, C; Rowe, PS; Garabédian, M; Meilhac, O. Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.. The American Journal of Pathology. August 2010, 177 (2): 803–12. PMC 2913338 . PMID 20581062. doi:10.2353/ajpath.2010.091231.

[auto-6] Longo, Dan L.; et al. Harrison's principles of internal medicine. 18th. New York: McGraw-Hill. 2012. ISBN 978-0-07174889-6.

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