1-氧雜-4,7-二氮雜環壬烷

1-氧雜-4,7-二氮雜環壬烷
識別
CAS號	80289-59-4
SMILES	O1CCNCCNCC1;
性質
化學式	C6H14N2O
摩爾質量	130.19 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

1-氧雜-4,7-二氮雜環壬烷是一種有機化合物，化學式為C₆H₁₄N₂O。它可由N,N'-二(4-甲苯磺醯基)乙二胺二鈉和二乙二醇二(4-甲苯磺酸)酯在乾燥的DMF中於110 °C反應，再在乙酸、48%氫溴酸和苯酚的混合溶液中回流製得。^[1]它和鹵代烷基化合物（如溴乙基氨二乙酸二叔丁酯、2-溴-1-(4-羥甲基-1-哌啶基)乙酮等）反應，可以得到4,7-二(取代烷基)-1-氧雜-4,7-二氮雜環壬烷。^[2]^[3]

參考文獻

^ Ana S. Fernandes, et al. Macrocyclic copper(II) complexes: Superoxide scavenging activity, structural studies and cytotoxicity evaluation. Journal of Inorganic Biochemistry, 2007. 101 (5): 849-858. doi:10.1016/j.jinorgbio.2007.01.013.
^ New 9- or 10-Dentate Luminescent Lanthanide Chelates. Bioconjugate Chem. 2008, 19, 5, 1105–1111. doi:10.1021/bc800030z
^ Botar, Richard; Garda, Zoltan; Fodor, Tamas; Kalman, Ferenc, Krisztian; Nagy, Viktoria; Tircso, Gyula; Toth, Imre. Triazacyclononane derivatives and their use as ligands in Mn(II)-based MRI contrast agents. 2017. HU2015000563 A2.

[1] Ana S. Fernandes, et al. Macrocyclic copper(II) complexes: Superoxide scavenging activity, structural studies and cytotoxicity evaluation. Journal of Inorganic Biochemistry, 2007. 101 (5): 849-858. doi:10.1016/j.jinorgbio.2007.01.013.

[2] New 9- or 10-Dentate Luminescent Lanthanide Chelates. Bioconjugate Chem. 2008, 19, 5, 1105–1111. doi:10.1021/bc800030z

[3] Botar, Richard; Garda, Zoltan; Fodor, Tamas; Kalman, Ferenc, Krisztian; Nagy, Viktoria; Tircso, Gyula; Toth, Imre. Triazacyclononane derivatives and their use as ligands in Mn(II)-based MRI contrast agents. 2017. HU2015000563 A2.

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