N-(9-芴甲氧羰基)天門冬氨酸-4-叔丁酯

N-(9-芴甲氧羰基)天門冬氨酸-4-叔丁酯
別名	Fmoc-L-Asp(OtBu)-OH; Fmoc-L-天冬氨酸-β-叔丁酯
識別
CAS號	71989-14-5（2S）
性質
化學式	C23H25NO6
摩爾質量	411.45 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

N-(9-芴甲氧羰基)天門冬氨酸-4-叔丁酯是一種有機化合物，化學式為C₂₃H₂₅NO₆。它可由天門冬氨酸-4-叔丁酯和氯甲酸-9-芴甲酯為原料反應得到。^[1]它和溴化苄在碳酸銫存在下反應，可以得到N-(9-芴甲氧羰基)天門冬氨酸-1-苄酯-4-叔丁酯，它可進一步被甲酸脫叔丁基後，由甲硼烷二甲硫醚將羧酸還原為醇。^[2]

參考文獻

^ Bolin, David R.; Sytwu, Iou Iou; Humiec, Frank; Meienhofer, Johannes. Preparation of oligomer-free N^α-Fmoc and N^α-urethane amino acids. International Journal of Peptide & Protein Research, 1989. 33 (5): 353-359. ISSN 0367-8377.
^ Dieuwertje E. Streefkerk; Marcel Schmidt; Johannes H. Ippel; Tilman M. Hackeng; Timo Nuijens; Peter Timmerman; Jan H. van Maarseveen. Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Org. Lett. 2019, 21, 7, 2095–2100. doi:10.1021/acs.orglett.9b00378.

[1] Bolin, David R.; Sytwu, Iou Iou; Humiec, Frank; Meienhofer, Johannes. Preparation of oligomer-free N^α-Fmoc and N^α-urethane amino acids. International Journal of Peptide & Protein Research, 1989. 33 (5): 353-359. ISSN 0367-8377.

[2] Dieuwertje E. Streefkerk; Marcel Schmidt; Johannes H. Ippel; Tilman M. Hackeng; Timo Nuijens; Peter Timmerman; Jan H. van Maarseveen. Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Org. Lett. 2019, 21, 7, 2095–2100. doi:10.1021/acs.orglett.9b00378.

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