Capan-1
Capan-1 (亦稱ATCC HTB-79) 是具有高侵襲性及高分化能力的人類胰腺癌細胞系，最初是分離自一名40歲的白人男性腺癌患者。
特徵
[编辑]Capan-1細胞對孕酮受體及雌激素受體α呈現陽性反應[1]，並且表達囊腫性纖維化跨膜電導調節因子[2]及分泌胃黏蛋白。CAPAN-1細胞對內毒素和腫瘤壞死因子-α都有濃度依賴性的IL-6和白細胞介素-8產生，白細胞介素-8的低水平表達不受任何濃度的脂多糖所影響。這些發現表明胰管細胞可能通過細胞因子的產生，積極參與着急性胰腺炎的發病機制[3]。在裸鼠體內生長的Capan-1細胞對5-氟尿嘧啶具有抗藥性，染色體編號在51至61號之間[4]。
參考資料
[编辑]- ^ Hollande, E; Fanjul, M; Houti, N; Faye, JC; Courriere, P. Expression of estrogen receptors during growth of human pancreatic adenocarcinoma cells (Capan-1)-relationship with differentiation.. In vitro cellular & developmental biology. Animal. NaN, 34 (7): 593–9 [2019-12-15]. PMID 9719420. doi:10.1007/s11626-998-0120-z. （原始内容存档于2019-12-15）.
- ^ Namkung, W; Lee, JA; Ahn, W; Han, W; Kwon, SW; Ahn, DS; Kim, KH; Lee, MG. Ca2+ activates cystic fibrosis transmembrane conductance regulator- and Cl- -dependent HCO3 transport in pancreatic duct cells.. The Journal of biological chemistry. 2003-01-03, 278 (1): 200–7 [2019-12-15]. PMID 12409301. doi:10.1074/jbc.M207199200. （原始内容存档于2019-12-15）.
- ^ Blanchard JA, 2nd; Barve, S; Joshi-Barve, S; Talwalker, R; Gates LK, Jr. Cytokine production by CAPAN-1 and CAPAN-2 cell lines.. Digestive diseases and sciences. 2000-05, 45 (5): 927–32 [2019-12-15]. PMID 10795756. doi:10.1023/a:1005573024448. （原始内容存档于2019-12-15）.
- ^ Kyriazis, AP; Kyriazis, AA; Scarpelli, DG; Fogh, J; Rao, MS; Lepera, R. Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics.. The American journal of pathology. 1982-02, 106 (2): 250–60 [2019-12-15]. PMID 6278935. （原始内容存档于2019-12-15）.