Capan-1
Capan-1 (亦称ATCC HTB-79) 是具有高侵袭性及高分化能力的人类胰腺癌细胞系，最初是分离自一名40岁的白人男性腺癌患者。
特征
[编辑]Capan-1细胞对孕酮受体及雌激素受体α呈现阳性反应[1]，并且表达囊肿性纤维化跨膜电导调节因子[2]及分泌胃黏蛋白。CAPAN-1细胞对内毒素和肿瘤坏死因子-α都有浓度依赖性的IL-6和白细胞介素-8产生，白细胞介素-8的低水平表达不受任何浓度的脂多糖所影响。这些发现表明胰管细胞可能通过细胞因子的产生，积极参与着急性胰腺炎的发病机制[3]。在裸鼠体内生长的Capan-1细胞对5-氟尿嘧啶具有抗药性，染色体编号在51至61号之间[4]。
参考资料
[编辑]- ^ Hollande, E; Fanjul, M; Houti, N; Faye, JC; Courriere, P. Expression of estrogen receptors during growth of human pancreatic adenocarcinoma cells (Capan-1)-relationship with differentiation.. In vitro cellular & developmental biology. Animal. NaN, 34 (7): 593–9 [2019-12-15]. PMID 9719420. doi:10.1007/s11626-998-0120-z. （原始内容存档于2019-12-15）.
- ^ Namkung, W; Lee, JA; Ahn, W; Han, W; Kwon, SW; Ahn, DS; Kim, KH; Lee, MG. Ca2+ activates cystic fibrosis transmembrane conductance regulator- and Cl- -dependent HCO3 transport in pancreatic duct cells.. The Journal of biological chemistry. 2003-01-03, 278 (1): 200–7 [2019-12-15]. PMID 12409301. doi:10.1074/jbc.M207199200. （原始内容存档于2019-12-15）.
- ^ Blanchard JA, 2nd; Barve, S; Joshi-Barve, S; Talwalker, R; Gates LK, Jr. Cytokine production by CAPAN-1 and CAPAN-2 cell lines.. Digestive diseases and sciences. 2000-05, 45 (5): 927–32 [2019-12-15]. PMID 10795756. doi:10.1023/a:1005573024448. （原始内容存档于2019-12-15）.
- ^ Kyriazis, AP; Kyriazis, AA; Scarpelli, DG; Fogh, J; Rao, MS; Lepera, R. Human pancreatic adenocarcinoma line Capan-1 in tissue culture and the nude mouse: morphologic, biologic, and biochemical characteristics.. The American journal of pathology. 1982-02, 106 (2): 250–60 [2019-12-15]. PMID 6278935. （原始内容存档于2019-12-15）.